C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: clathrin, heavy chain (Hc)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141367 CLTC 9606 + 17:59619689-59696956 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000269122 CLTC-001 59619858-59696310 protein_coding
  ENST00000393043 CLTC-002 59619858-59690826 protein_coding
  ENST00000466513 CLTC-006 59664690-59667066 retained_intron
  ENST00000472129 CLTC-004 59648240-59656231 retained_intron
  ENST00000472651 CLTC-008 59683906-59693822 protein_coding
  ENST00000475458 CLTC-009 59685117-59687147 protein_coding
  ENST00000483176 CLTC-005 59655961-59663992 nonsense_mediated_decay
  ENST00000496076 CLTC-007 59683714-59684509 retained_intron
  ENST00000498711 CLTC-003 59689156-59695112 retained_intron
  ENST00000579456 CLTC-010 59619932-59694114 protein_coding
  ENST00000579815 CLTC-012 59670982-59677141 processed_transcript
  ENST00000580081 CLTC-014 59619924-59647502 protein_coding
  ENST00000584313 CLTC-011 59619943-59651316 nonsense_mediated_decay
  ENST00000585198 CLTC-013 59647646-59648695 retained_intron
  ENST00000621829 CLTC-201 59619689-59696956 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000269122ENST00000393043ENST00000498711ENST00000579456
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000269122 4.287±0.00 19.799±0.00 N/A 8.110±0.00 N/A 5.534±0.00 9.616±0.00 N/A N/A 17.423±5.48 23.487±19.92 24.736±0.00
ENST00000393043 N/A 47.636±0.00 33.218±0.00 33.759±0.00 6.720±0.00 24.824±0.00 N/A 33.060±0.00 8.061±0.00 29.327±14.72 N/A N/A
ENST00000498711 N/A N/A N/A N/A N/A N/A N/A N/A N/A 39.601±0.00 58.950±0.00 34.841±0.00
ENST00000579456 N/A N/A N/A N/A N/A N/A N/A N/A N/A 38.662±0.00 52.241±0.00 27.715±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081F CIL_00081F_0001 VISTA 17:59485788-60087415
CIL_0008Y2 CIL_0008Y2_0001 VISTA 17:59536739-60138754
CIL_0008VS CIL_0008VS_0001 VISTA 17:59556856-60159441
CIL_000568 CIL_000568_0002 CGP 17:59565525-59696956

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001649 IDA osteoblast differentiation
GO:0003725 IDA double-stranded RNA binding
GO:0005198 NAS:IEA structural molecule activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005819 IDA spindle
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006886 NAS:IEA intracellular protein transport
GO:0006892 TAS post-Golgi vesicle-mediated transport
GO:0006898 IMP receptor-mediated endocytosis
GO:0007067 IMP mitotic nuclear division
GO:0016020 IDA membrane
GO:0016192 IEA vesicle-mediated transport
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 ISS protein kinase binding
GO:0030117 IEA membrane coat
GO:0030118 NAS clathrin coat
GO:0030130 IEA clathrin coat of trans-Golgi network vesicle
GO:0030132 IEA clathrin coat of coated pit
GO:0030136 IDA clathrin-coated vesicle
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0031623 IMP receptor internalization
GO:0031982 IDA vesicle
GO:0032051 IPI clathrin light chain binding
GO:0032588 TAS trans-Golgi network membrane
GO:0033572 IMP transferrin transport
GO:0043234 IDA protein complex
GO:0044822 IDA poly(A) RNA binding
GO:0061024 TAS membrane organization
GO:0070062 IDA extracellular vesicular exosome
GO:0071439 IDA clathrin complex
GO:1900126 IMP negative regulation of hyaluronan biosynthetic process
GO:1903077 IMP negative regulation of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043493 cltca clathrin, heavy polypeptide a (Hc) protein_coding Danio_rerio
ENSDARG00000090716 cltcb clathrin, heavy polypeptide b (Hc) protein_coding Danio_rerio
ENSMUSG00000047126 Cltc clathrin, heavy polypeptide (Hc) protein_coding Mus_musculus

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