C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141655 TNFRSF11A 9606 + 18:62325287-62391292 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000269485 TNFRSF11A-002 62325287-62387659 protein_coding
  ENST00000586569 TNFRSF11A-001 62325315-62391292 protein_coding
  ENST00000587697 TNFRSF11A-004 62357903-62360043 retained_intron
  ENST00000592013 TNFRSF11A-003 62325326-62336786 retained_intron
  ENST00000616710 TNFRSF11A-201 62325287-62387710 protein_coding
  ENST00000617039 TNFRSF11A-202 62325287-62387710 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000269485ENST00000586569ENST00000587697ENST00000592013ENST00000616710ENST00000617039
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000269485 N/A 0.999±0.00 N/A 1.009±0.20 1.297±0.00 N/A 0.536±0.00 0.348±0.29 N/A N/A 0.868±0.76 0.979±0.13 0.439±0.00
ENST00000586569 0.091±0.00 1.094±0.00 N/A 0.355±0.00 0.712±0.51 0.085±0.00 0.180±0.00 0.070±0.05 0.094±0.05 0.028±0.00 0.194±0.13 0.624±0.20 0.254±0.07
ENST00000587697 N/A N/A N/A N/A N/A N/A N/A N/A 0.222±0.00 N/A N/A N/A N/A
ENST00000592013 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.271±0.00 N/A N/A N/A
ENST00000616710 0.249±0.00 1.019±0.00 0.344±0.08 N/A 4.051±0.00 0.271±0.00 N/A N/A 0.183±0.00 N/A 1.141±0.00 1.100±0.38 0.691±0.00
ENST00000617039 N/A N/A N/A 0.391±0.00 0.397±0.00 N/A 0.142±0.00 0.046±0.00 0.088±0.00 N/A 0.111±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00071U CIL_00071U_0001 CGP 18:62187258-62391292
CIL_00076G CIL_00076G_0001 CGP 18:62325287-62587709

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IEA ossification
GO:0002250 IMP adaptive immune response
GO:0002548 NAS monocyte chemotaxis
GO:0004872 TAS receptor activity
GO:0004888 IDA transmembrane signaling receptor activity
GO:0005031 ISS tumor necrosis factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0007275 IEA multicellular organismal development
GO:0008284 TAS positive regulation of cell proliferation
GO:0009314 IEA response to radiation
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0016021 IEA integral component of membrane
GO:0019955 IPI cytokine binding
GO:0030316 IMP osteoclast differentiation
GO:0032496 ISS response to lipopolysaccharide
GO:0033209 ISS tumor necrosis factor-mediated signaling pathway
GO:0034097 IMP response to cytokine
GO:0034612 ISS response to tumor necrosis factor
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0046872 IEA metal ion binding
GO:0048535 IEA lymph node development
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0060086 ISS circadian temperature homeostasis
GO:0060749 IEA mammary gland alveolus development
GO:0070555 ISS response to interleukin-1
GO:0071812 ISS positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 IMP TNFSF11-mediated signaling pathway
GO:0071848 IMP positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087804 CT573348.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000026321 Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator protein_coding Mus_musculus

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