C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000269485 TNFRSF11A-002 ENSG00000141655 9606 + 18:62325287-62387659 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonKidneyLiverOvaryPlacentaTestisENST00000269485
Transcript ID Adrenal Breast Colon Kidney Liver Ovary Placenta Testis
ENST00000269485 0.999±0.00 1.009±0.20 1.297±0.00 0.536±0.00 0.348±0.29 0.868±0.76 0.979±0.13 0.439±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00071U CIL_00071U_0001 CGP 18:62187258-62391292
CIL_00076G CIL_00076G_0001 CGP 18:62325287-62587709

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002250 IMP adaptive immune response
GO:0002548 NAS monocyte chemotaxis
GO:0004872 TAS receptor activity
GO:0004888 IDA transmembrane signaling receptor activity
GO:0005031 ISS tumor necrosis factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0008284 TAS positive regulation of cell proliferation
GO:0009897 IDA external side of plasma membrane
GO:0016021 IEA integral component of membrane
GO:0019955 IPI cytokine binding
GO:0030316 IMP osteoclast differentiation
GO:0032496 ISS response to lipopolysaccharide
GO:0033209 ISS tumor necrosis factor-mediated signaling pathway
GO:0034097 IMP response to cytokine
GO:0034612 ISS response to tumor necrosis factor
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0046872 IEA metal ion binding
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0060086 ISS circadian temperature homeostasis
GO:0070555 ISS response to interleukin-1
GO:0071812 ISS positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 IMP TNFSF11-mediated signaling pathway
GO:0071848 IMP positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000027559 Tnfrsf11a-001 protein_coding Mus_musculus 0 590
ENSMUST00000187812 Tnfrsf11a-002 retained_intron Mus_musculus 0 433

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