C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: heat shock 60kDa protein 1 (chaperonin)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000144381 HSPD1 9606 - 2:197486581-197516737 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000345042 HSPD1-201 197486586-197500274 protein_coding
  ENST00000388968 HSPD1-001 197486581-197500047 protein_coding
  ENST00000418022 HSPD1-012 197498674-197499840 protein_coding
  ENST00000426480 HSPD1-009 197497168-197516737 protein_coding
  ENST00000428204 HSPD1-010 197497285-197499866 protein_coding
  ENST00000430176 HSPD1-013 197494148-197500208 protein_coding
  ENST00000439605 HSPD1-011 197497317-197499835 protein_coding
  ENST00000440114 HSPD1-007 197494640-197499822 nonsense_mediated_decay
  ENST00000452200 HSPD1-006 197494194-197500221 protein_coding
  ENST00000461097 HSPD1-014 197496891-197499817 retained_intron
  ENST00000476746 HSPD1-008 197495051-197499879 retained_intron
  ENST00000482167 HSPD1-004 197493320-197494474 retained_intron
  ENST00000486181 HSPD1-005 197494150-197497507 retained_intron
  ENST00000491249 HSPD1-003 197487974-197490572 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000345042ENST00000388968
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000345042 N/A 14.459±0.00 8.827±0.00 N/A N/A N/A N/A 19.470±4.17 N/A N/A 1.316±0.00 32.405±12.49 39.871±22.45 22.333±2.04
ENST00000388968 42.857±0.00 22.990±0.00 10.981±0.00 20.737±9.46 30.253±15.37 67.372±47.34 12.188±8.84 52.562±28.37 62.740±51.62 36.228±25.32 24.364±0.00 98.270±77.55 36.872±5.22 22.618±8.96

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007X7 CIL_0007X7_0001 VISTA 2:196975905-197591368
CIL_0002KH CIL_0002KH_0001 CGP 2:197453423-197516737
CIL_00042Q CIL_00042Q_0002 CGP 2:197486581-197516737

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001530 IDA lipopolysaccharide binding
GO:0002039 IPI p53 binding
GO:0002368 IDA B cell cytokine production
GO:0002755 IDA MyD88-dependent toll-like receptor signaling pathway
GO:0002842 IDA positive regulation of T cell mediated immune response to tumor cell
GO:0003688 ISS DNA replication origin binding
GO:0003697 ISS single-stranded DNA binding
GO:0003725 IDA double-stranded RNA binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005737 IDA:IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005743 ISS mitochondrial inner membrane
GO:0005759 TAS mitochondrial matrix
GO:0005769 IDA early endosome
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0005905 IDA coated pit
GO:0006200 ISS ATP catabolic process
GO:0006458 ISS 'de novo' protein folding
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986 IDA response to unfolded protein
GO:0009986 IDA cell surface
GO:0016020 IDA membrane
GO:0016032 IEA viral process
GO:0016887 ISS ATPase activity
GO:0019907 IDA cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030135 IDA coated vesicle
GO:0030141 ISS secretory granule
GO:0032727 IDA positive regulation of interferon-alpha production
GO:0032729 ISS positive regulation of interferon-gamma production
GO:0032733 IDA positive regulation of interleukin-10 production
GO:0032735 IDA positive regulation of interleukin-12 production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0042026 IDA:IEA protein refolding
GO:0042100 IDA B cell proliferation
GO:0042110 IDA T cell activation
GO:0042113 IDA B cell activation
GO:0043032 IDA positive regulation of macrophage activation
GO:0043065 IMP positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IDA protein complex
GO:0044267 IEA cellular protein metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0046696 IDA lipopolysaccharide receptor complex
GO:0048291 IDA isotype switching to IgG isotypes
GO:0050821 ISS protein stabilization
GO:0050870 ISS positive regulation of T cell activation
GO:0051082 ISS unfolded protein binding
GO:0051087 IPI chaperone binding
GO:0051131 ISS chaperone-mediated protein complex assembly
GO:0051604 ISS protein maturation
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056160 hspd1 heat shock 60kD protein 1 (chaperonin) protein_coding Danio_rerio
ENSMUSG00000025980 Hspd1 heat shock protein 1 (chaperonin) protein_coding Mus_musculus

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