C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mesencephalic astrocyte-derived neurotrophic factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145050 MANF 9606 + 3:51385047-51389397 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000446668 MANF-003 51385357-51389262 nonsense_mediated_decay
  ENST00000470900 MANF-002 51385409-51389344 processed_transcript
  ENST00000482262 MANF-004 51387688-51389149 retained_intron
  ENST00000528157 MANF-001 51385047-51389397 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000446668ENST00000470900ENST00000482262ENST00000528157
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000446668 N/A N/A N/A N/A N/A N/A N/A 1.370±0.00 N/A 9.440±0.00 N/A N/A N/A N/A
ENST00000470900 N/A N/A N/A 0.573±0.00 N/A N/A N/A N/A N/A 0.903±0.00 N/A N/A N/A N/A
ENST00000482262 12.200±0.00 18.212±0.00 N/A 5.966±0.00 11.990±0.00 19.344±14.63 10.553±0.00 46.478±41.78 68.483±0.00 24.429±21.93 3.476±3.20 24.266±2.27 32.254±7.51 28.906±0.02
ENST00000528157 20.560±0.00 22.691±0.00 1.630±0.00 6.078±2.65 13.306±1.78 28.348±22.91 6.204±3.86 38.362±33.57 25.610±21.68 20.933±18.16 2.475±2.12 24.620±17.10 35.926±7.12 34.612±14.96

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003FL CIL_0003FL_0002 CGP 3:50675241-51389397
CIL_0005MV CIL_0005MV_0002 CGP 3:51385047-51397908

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002014 IEA vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
GO:0005615 IEA extracellular space
GO:0005634 IDA nucleus
GO:0005783 IEA endoplasmic reticulum
GO:0006986 IEA response to unfolded protein
GO:0008083 IEA growth factor activity
GO:0008150 ND biological_process
GO:0044822 IDA poly(A) RNA binding
GO:0048471 IEA perinuclear region of cytoplasm

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063177 manf mesencephalic astrocyte-derived neurotrophic factor protein_coding Danio_rerio
ENSMUSG00000032575 Manf mesencephalic astrocyte-derived neurotrophic factor protein_coding Mus_musculus

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