C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: platelet derived growth factor C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145431 PDGFC 9606 - 4:156760454-156971394 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000274071 PDGFC-002 156761614-156971315 nonsense_mediated_decay
  ENST00000422544 PDGFC-009 156763090-156970903 protein_coding
  ENST00000502773 PDGFC-001 156760454-156971394 protein_coding
  ENST00000504672 PDGFC-007 156762803-156773717 processed_transcript
  ENST00000506880 PDGFC-003 156762948-156850272 nonsense_mediated_decay
  ENST00000510982 PDGFC-006 156767782-156774478 processed_transcript
  ENST00000511985 PDGFC-008 156770182-156810891 processed_transcript
  ENST00000512711 PDGFC-005 156772789-156873972 processed_transcript
  ENST00000513664 PDGFC-004 156967329-156970965 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000274071ENST00000422544ENST00000502773ENST00000504672ENST00000506880ENST00000510982ENST00000512711
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000274071 3.315±0.00 3.292±0.00 2.739±0.00 1.318±0.06 5.351±1.10 1.248±0.00 2.113±1.35 2.713±0.26 2.371±1.04 1.667±0.72 2.230±0.00 4.732±2.67 3.887±0.93 2.233±1.45
ENST00000422544 3.750±0.00 N/A N/A 1.040±0.00 N/A N/A N/A N/A N/A N/A 0.286±0.00 1.243±0.00 3.618±0.00 0.816±0.00
ENST00000502773 N/A N/A N/A N/A N/A 0.460±0.00 0.170±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000504672 N/A N/A N/A 1.903±0.00 N/A 1.745±0.00 N/A N/A N/A 2.846±0.00 2.749±0.00 N/A N/A N/A
ENST00000506880 N/A N/A N/A N/A N/A N/A N/A N/A 2.787±0.00 N/A N/A N/A N/A N/A
ENST00000510982 N/A N/A N/A N/A N/A N/A 2.180±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000512711 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.724±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006DW CIL_0006DW_0002 CGP 4:156760454-157172090

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0005161 IPI platelet-derived growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005886 IDA plasma membrane
GO:0007171 IEA activation of transmembrane receptor protein tyrosine kinase activity
GO:0007417 TAS central nervous system development
GO:0008083 IEA growth factor activity
GO:0008284 IEA positive regulation of cell proliferation
GO:0009887 IEA organ morphogenesis
GO:0009986 IDA cell surface
GO:0016020 IEA membrane
GO:0042803 IPI protein homodimerization activity
GO:0045740 IDA positive regulation of DNA replication
GO:0048008 IDA platelet-derived growth factor receptor signaling pathway
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0050730 IEA regulation of peptidyl-tyrosine phosphorylation
GO:0051781 IEA positive regulation of cell division
GO:0070062 IDA extracellular vesicular exosome
GO:0071230 IEA cellular response to amino acid stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077588 PDGFC platelet derived growth factor C protein_coding Danio_rerio
ENSMUSG00000028019 Pdgfc platelet-derived growth factor, C polypeptide protein_coding Mus_musculus

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