C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: FYVE, RhoGEF and PH domain containing 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000146192 FGD2 9606 + 6:37005646-37029070 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000274963 FGD2-001 37005647-37029070 protein_coding
  ENST00000373535 FGD2-003 37005655-37028488 nonsense_mediated_decay
  ENST00000459781 FGD2-012 37005658-37012033 retained_intron
  ENST00000464083 FGD2-006 37005699-37028538 retained_intron
  ENST00000470273 FGD2-008 37013234-37020717 retained_intron
  ENST00000487920 FGD2-010 37021542-37029069 retained_intron
  ENST00000487975 FGD2-005 37005699-37011563 retained_intron
  ENST00000489356 FGD2-002 37005646-37010031 retained_intron
  ENST00000493635 FGD2-009 37013502-37028546 retained_intron
  ENST00000494343 FGD2-007 37013025-37029069 retained_intron
  ENST00000497659 FGD2-011 37005655-37011034 nonsense_mediated_decay

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000274963ENST00000373535ENST00000459781ENST00000464083ENST00000487920ENST00000487975ENST00000489356ENST00000493635ENST00000494343ENST00000497659
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000274963 1.332±0.00 11.127±0.00 N/A 1.066±0.00 0.644±0.10 0.158±0.00 1.083±0.00 2.239±0.00 0.935±0.00 3.098±0.00 N/A 0.654±0.37 3.003±1.35 0.598±0.00
ENST00000373535 0.693±0.00 N/A N/A N/A 0.549±0.00 N/A N/A N/A 1.267±0.00 1.564±0.00 0.081±0.00 N/A N/A 0.651±0.00
ENST00000459781 N/A N/A N/A N/A N/A N/A 0.722±0.00 N/A N/A N/A N/A 0.715±0.00 N/A N/A
ENST00000464083 0.553±0.00 N/A 0.062±0.00 N/A N/A N/A 0.277±0.00 N/A N/A 1.029±0.00 N/A 0.575±0.19 1.140±0.00 N/A
ENST00000487920 N/A N/A N/A N/A N/A N/A N/A N/A 0.271±0.00 N/A N/A 0.307±0.00 N/A 0.198±0.00
ENST00000487975 N/A N/A 0.240±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000489356 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.274±0.00 0.028±0.00 N/A N/A N/A
ENST00000493635 N/A N/A N/A 0.043±0.00 N/A N/A N/A 0.324±0.00 N/A N/A 0.029±0.00 0.092±0.04 N/A N/A
ENST00000494343 0.650±0.00 3.954±0.00 0.423±0.00 0.225±0.00 0.534±0.00 0.152±0.00 0.572±0.00 N/A 0.261±0.00 1.353±0.00 N/A N/A 1.364±0.00 N/A
ENST00000497659 N/A N/A N/A N/A N/A N/A 1.046±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089L CIL_00089L_0001 VISTA 6:36799205-37399713
CIL_0002Y4 CIL_0002Y4_0001 CGP 6:36968141-37029070
CIL_0002Y3 CIL_0002Y3_0001 CGP 6:37005646-37175426

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005768 IEA endosome
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0007010 ISS cytoskeleton organization
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008360 ISS regulation of cell shape
GO:0030027 ISS lamellipodium
GO:0030036 ISS actin cytoskeleton organization
GO:0031267 ISS small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043547 ISS positive regulation of GTPase activity
GO:0046847 ISS filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000024013 Fgd2 FYVE, RhoGEF and PH domain containing 2 protein_coding Mus_musculus

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