C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: FYVE, RhoGEF and PH domain containing 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000274963 FGD2-001 ENSG00000146192 9606 + 6:37005647-37029070 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000274963
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000274963 1.332±0.00 11.127±0.00 1.066±0.00 0.644±0.10 0.158±0.00 1.083±0.00 2.239±0.00 0.935±0.00 3.098±0.00 0.654±0.37 3.003±1.35 0.598±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089L CIL_00089L_0001 VISTA 6:36799205-37399713
CIL_0002Y4 CIL_0002Y4_0001 CGP 6:36968141-37029070
CIL_0002Y3 CIL_0002Y3_0001 CGP 6:37005646-37175426

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005768 IEA endosome
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0007010 ISS cytoskeleton organization
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008360 ISS regulation of cell shape
GO:0030027 ISS lamellipodium
GO:0030036 ISS actin cytoskeleton organization
GO:0031267 ISS small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043547 ISS positive regulation of GTPase activity
GO:0046847 ISS filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000024810 Fgd2-001 protein_coding Mus_musculus 0 1796
ENSMUST00000123989 Fgd2-002 nonsense_mediated_decay Mus_musculus 0 1158
ENSMUST00000137644 Fgd2-005 retained_intron Mus_musculus 0 490
ENSMUST00000138537 Fgd2-008 retained_intron Mus_musculus 0 329
ENSMUST00000125620 Fgd1-004 retained_intron Mus_musculus 0.00000009 64
ENSMUST00000026296 Fgd1-001 protein_coding Mus_musculus 0.00000009 64
ENSMUST00000112685 Fgd1-002 protein_coding Mus_musculus 0.00000009 64

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