C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000150093 ITGB1 9606 - 10:32900319-33005792 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302278 ITGB1-001 32900392-32958209 protein_coding
  ENST00000396033 ITGB1-201 32900319-32957894 protein_coding
  ENST00000414670 ITGB1-002 32932521-32958196 protein_coding
  ENST00000417122 ITGB1-003 32929929-32958227 protein_coding
  ENST00000423113 ITGB1-202 32900319-32935558 protein_coding
  ENST00000437302 ITGB1-006 32928232-32957794 protein_coding
  ENST00000439974 ITGB1-017 32958486-32960503 retained_intron
  ENST00000464001 ITGB1-008 32929932-32932717 retained_intron
  ENST00000472147 ITGB1-013 32929985-32936251 protein_coding
  ENST00000474568 ITGB1-004 32928174-32958232 protein_coding
  ENST00000475184 ITGB1-012 32929824-33005792 protein_coding
  ENST00000480226 ITGB1-009 32928150-32955663 protein_coding
  ENST00000484088 ITGB1-011 32925961-32958218 processed_transcript
  ENST00000488427 ITGB1-005 32900992-32908503 protein_coding
  ENST00000488494 ITGB1-010 32928193-32958227 protein_coding
  ENST00000493758 ITGB1-007 32929934-32935558 protein_coding
  ENST00000494395 ITGB1-014 32901564-32912064 nonsense_mediated_decay
  ENST00000528877 ITGB1-015 32929885-32963283 protein_coding
  ENST00000534049 ITGB1-016 32928212-32992463 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302278ENST00000396033ENST00000423113
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302278 143.957±0.00 72.924±0.00 24.820±0.00 15.904±7.67 143.425±47.25 103.076±46.49 28.691±11.07 56.586±14.18 70.966±7.44 125.948±60.18 9.993±0.37 51.821±19.55 64.708±19.23 64.603±28.85
ENST00000396033 19.876±0.00 43.321±0.00 N/A 4.425±0.00 75.666±0.00 40.224±0.00 N/A 24.937±0.00 11.169±3.40 N/A N/A 38.660±29.16 99.414±26.01 47.681±0.00
ENST00000423113 N/A N/A N/A N/A N/A N/A 21.335±2.59 N/A N/A N/A 26.409±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006FV CIL_0006FV_0002 CGP 10:32900319-33336262

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IEA G1/S transition of mitotic cell cycle
GO:0001618 IEA virus receptor activity
GO:0001669 IEA acrosomal vesicle
GO:0001701 IEA in utero embryonic development
GO:0001708 IEA cell fate specification
GO:0001726 TAS ruffle
GO:0001894 IEA tissue homeostasis
GO:0001948 IEA glycoprotein binding
GO:0001968 IEA fibronectin binding
GO:0002020 IPI protease binding
GO:0002042 IEA cell migration involved in sprouting angiogenesis
GO:0003779 IDA actin binding
GO:0004872 IEA receptor activity
GO:0005102 IEA receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005518 IEA collagen binding
GO:0005604 IEA basement membrane
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005886 NAS plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005912 IEA adherens junction
GO:0005925 IDA focal adhesion
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006968 TAS cellular defense response
GO:0007155 IEA cell adhesion
GO:0007156 TAS homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007161 IGI calcium-independent cell-matrix adhesion
GO:0007229 IMP integrin-mediated signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008305 NAS integrin complex
GO:0008354 IEA germ cell migration
GO:0008542 IEA visual learning
GO:0009615 IEA response to virus
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010710 IDA regulation of collagen catabolic process
GO:0010811 IEA positive regulation of cell-substrate adhesion
GO:0010976 IEA positive regulation of neuron projection development
GO:0014704 IEA intercalated disc
GO:0014823 IEA response to activity
GO:0016020 IDA:IEA membrane
GO:0016032 IEA viral process
GO:0016477 TAS cell migration
GO:0019900 IEA kinase binding
GO:0019901 IEA protein kinase binding
GO:0019904 IEA protein domain specific binding
GO:0021943 IEA formation of radial glial scaffolds
GO:0030056 IEA hemidesmosome
GO:0030175 IDA filopodium
GO:0030183 IC B cell differentiation
GO:0030198 TAS extracellular matrix organization
GO:0030335 IEA positive regulation of cell migration
GO:0031175 IEA neuron projection development
GO:0031345 IEA negative regulation of cell projection organization
GO:0031589 IMP cell-substrate adhesion
GO:0031594 IDA neuromuscular junction
GO:0031667 IEA response to nutrient levels
GO:0032403 IEA protein complex binding
GO:0032587 NAS ruffle membrane
GO:0032594 IEA protein transport within lipid bilayer
GO:0033631 IEP cell-cell adhesion mediated by integrin
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0034329 TAS cell junction assembly
GO:0034665 IDA integrin alpha1-beta1 complex
GO:0034666 IDA integrin alpha2-beta1 complex
GO:0034667 IDA integrin alpha3-beta1 complex
GO:0034677 IEA integrin alpha7-beta1 complex
GO:0034678 TAS integrin alpha8-beta1 complex
GO:0034679 IEA integrin alpha9-beta1 complex
GO:0034680 IDA integrin alpha10-beta1 complex
GO:0034681 IDA integrin alpha11-beta1 complex
GO:0034698 IEA response to gonadotropin
GO:0035024 IEA negative regulation of Rho protein signal transduction
GO:0035748 IEA myelin sheath abaxonal region
GO:0042277 IEA peptide binding
GO:0042383 IDA sarcolemma
GO:0042493 IEA response to drug
GO:0043065 IGI positive regulation of apoptotic process
GO:0043197 IEA dendritic spine
GO:0043235 IDA receptor complex
GO:0043236 IEA laminin binding
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045121 IDA membrane raft
GO:0045202 IEA synapse
GO:0045214 IEA sarcomere organization
GO:0045596 IEA negative regulation of cell differentiation
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045807 IEA positive regulation of endocytosis
GO:0046872 IEA metal ion binding
GO:0046982 IDA protein heterodimerization activity
GO:0048333 IEP mesodermal cell differentiation
GO:0048675 IEA axon extension
GO:0048738 IEA cardiac muscle tissue development
GO:0048813 IEA dendrite morphogenesis
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 TAS regulation of immune response
GO:0050839 IPI cell adhesion molecule binding
GO:0050900 TAS leukocyte migration
GO:0050901 IMP leukocyte tethering or rolling
GO:0051393 IEA alpha-actinin binding
GO:0051726 IEA regulation of cell cycle
GO:0055007 IEA cardiac muscle cell differentiation
GO:0060135 IEA maternal process involved in female pregnancy
GO:0070062 IDA extracellular vesicular exosome
GO:0070830 IEA tight junction assembly
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071305 IEA cellular response to vitamin D
GO:0071438 IDA invadopodium membrane
GO:0071479 IEA cellular response to ionizing radiation
GO:0071559 IEA response to transforming growth factor beta
GO:0090004 IDA positive regulation of establishment of protein localization to plasma membrane
GO:0097060 IEA synaptic membrane
GO:0098639 IMP collagen binding involved in cell-matrix adhesion
GO:2000811 IMP negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022689 itgb1b.2 integrin, beta 1b.2 protein_coding Danio_rerio
ENSDARG00000053232 itgb1b.1 integrin, beta 1b.1 protein_coding Danio_rerio
ENSDARG00000053255 itgb1b integrin, beta 1b protein_coding Danio_rerio
ENSDARG00000071863 itgb1a integrin, beta 1a protein_coding Danio_rerio
ENSMUSG00000025809 Itgb1 integrin beta 1 (fibronectin receptor beta) protein_coding Mus_musculus

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