C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000302278 ITGB1-001 ENSG00000150093 9606 - 10:32900392-32958209 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302278
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302278 143.957±0.00 72.924±0.00 24.820±0.00 15.904±7.67 143.425±47.25 103.076±46.49 28.691±11.07 56.586±14.18 70.966±7.44 125.948±60.18 9.993±0.37 51.821±19.55 64.708±19.23 64.603±28.85

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006FV CIL_0006FV_0002 CGP 10:32900319-33336262

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001618 IEA virus receptor activity
GO:0001726 TAS ruffle
GO:0002020 IPI protease binding
GO:0003779 IDA actin binding
GO:0004872 IEA receptor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005886 NAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006968 TAS cellular defense response
GO:0007156 TAS homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007161 IGI calcium-independent cell-matrix adhesion
GO:0007229 IMP integrin-mediated signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008305 NAS integrin complex
GO:0009615 IEA response to virus
GO:0009986 IDA cell surface
GO:0010710 IDA regulation of collagen catabolic process
GO:0016020 IDA:IEA membrane
GO:0016032 IEA viral process
GO:0016477 TAS cell migration
GO:0030175 IDA filopodium
GO:0030183 IC B cell differentiation
GO:0030198 TAS extracellular matrix organization
GO:0031589 IMP cell-substrate adhesion
GO:0031594 IDA neuromuscular junction
GO:0032587 NAS ruffle membrane
GO:0033631 IEP cell-cell adhesion mediated by integrin
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0034329 TAS cell junction assembly
GO:0034665 IDA integrin alpha1-beta1 complex
GO:0034666 IDA integrin alpha2-beta1 complex
GO:0034667 IDA integrin alpha3-beta1 complex
GO:0034678 TAS integrin alpha8-beta1 complex
GO:0034680 IDA integrin alpha10-beta1 complex
GO:0034681 IDA integrin alpha11-beta1 complex
GO:0042383 IDA sarcolemma
GO:0043065 IGI positive regulation of apoptotic process
GO:0043235 IDA receptor complex
GO:0045121 IDA membrane raft
GO:0046872 IEA metal ion binding
GO:0046982 IDA protein heterodimerization activity
GO:0048333 IEP mesodermal cell differentiation
GO:0050776 TAS regulation of immune response
GO:0050839 IPI cell adhesion molecule binding
GO:0050900 TAS leukocyte migration
GO:0050901 IMP leukocyte tethering or rolling
GO:0070062 IDA extracellular vesicular exosome
GO:0071438 IDA invadopodium membrane
GO:0090004 IDA positive regulation of establishment of protein localization to plasma membrane
GO:0098639 IMP collagen binding involved in cell-matrix adhesion
GO:2000811 IMP negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000090006 Itgb1-001 protein_coding Mus_musculus 0 3025
ENSMUST00000124826 Itgb1-002 nonsense_mediated_decay Mus_musculus 0 2599
ENSMUST00000135281 Itgb1-003 retained_intron Mus_musculus 0 431
ENSMUST00000149116 Itgb1-004 protein_coding Mus_musculus 0 353

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