C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin beta 1 (fibronectin receptor beta)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025809 Itgb1 10090 + 8:128685654-128733200 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000090006 Itgb1-001 128685654-128733200 protein_coding
  ENSMUST00000124826 Itgb1-002 128685757-128732617 nonsense_mediated_decay
  ENSMUST00000135281 Itgb1-003 128685870-128710660 retained_intron
  ENSMUST00000149116 Itgb1-004 128724333-128732389 protein_coding

Mus musculus EnsemblGRCm38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000090006ENSMUST00000124826
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000090006 46.059±2.45 19.752±3.35 202.938±7.81 20.019±9.56 29.303±6.14 25.956±10.49 55.361±4.25 39.253±7.40 33.005±11.58 63.201±8.28 33.396±1.17 49.274±28.51 101.331±22.52 5.018±0.96
ENSMUST00000124826 29.195±11.10 20.460±2.36 N/A 3.657±0.00 13.931±3.87 25.689±9.34 N/A 11.808±3.57 5.177±0.98 45.477±6.46 N/A 30.884±11.41 36.196±16.77 3.133±2.55

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000CP CIL_0000CP_0002 CGP 8:128359073-128733200

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0001669 IEA acrosomal vesicle
GO:0001701 IMP in utero embryonic development
GO:0001708 IMP cell fate specification
GO:0001894 IEA tissue homeostasis
GO:0001948 IEA glycoprotein binding
GO:0001968 IEA fibronectin binding
GO:0002020 IEA protease binding
GO:0002042 IMP cell migration involved in sprouting angiogenesis
GO:0003779 IEA actin binding
GO:0004872 IEA receptor activity
GO:0005102 IEA receptor binding
GO:0005178 IPI integrin binding
GO:0005515 IPI protein binding
GO:0005518 IEA collagen binding
GO:0005604 IEA basement membrane
GO:0005737 IEA cytoplasm
GO:0005768 IEA endosome
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005912 IEA adherens junction
GO:0005925 IEA focal adhesion
GO:0006874 IEA cellular calcium ion homeostasis
GO:0007155 IEA cell adhesion
GO:0007159 IEA leukocyte cell-cell adhesion
GO:0007160 IGI cell-matrix adhesion
GO:0007161 IEA calcium-independent cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008354 IMP germ cell migration
GO:0008542 IGI visual learning
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010710 ISS regulation of collagen catabolic process
GO:0010811 IEA positive regulation of cell-substrate adhesion
GO:0010976 IEA positive regulation of neuron projection development
GO:0014704 IDA intercalated disc
GO:0014823 IEA response to activity
GO:0016477 IMP cell migration
GO:0019900 IEA kinase binding
GO:0019901 IEA protein kinase binding
GO:0019904 IEA protein domain specific binding
GO:0021943 IMP formation of radial glial scaffolds
GO:0030056 IEA hemidesmosome
GO:0030175 IEA filopodium
GO:0030335 IEA positive regulation of cell migration
GO:0031175 IMP neuron projection development
GO:0031345 IEA negative regulation of cell projection organization
GO:0031589 IEA cell-substrate adhesion
GO:0031594 IDA neuromuscular junction
GO:0031667 IEA response to nutrient levels
GO:0032403 IEA protein complex binding
GO:0032594 IEA protein transport within lipid bilayer
GO:0033631 IEA cell-cell adhesion mediated by integrin
GO:0034113 IEA heterotypic cell-cell adhesion
GO:0034665 IEA integrin alpha1-beta1 complex
GO:0034666 IEA integrin alpha2-beta1 complex
GO:0034667 IEA integrin alpha3-beta1 complex
GO:0034677 IPI integrin alpha7-beta1 complex
GO:0034679 IEA integrin alpha9-beta1 complex
GO:0034680 IEA integrin alpha10-beta1 complex
GO:0034681 IEA integrin alpha11-beta1 complex
GO:0034698 IEA response to gonadotropin
GO:0035024 IGI negative regulation of Rho protein signal transduction
GO:0035748 IDA myelin sheath abaxonal region
GO:0042277 IEA peptide binding
GO:0042383 IDA sarcolemma
GO:0042493 IEA response to drug
GO:0043065 IEA positive regulation of apoptotic process
GO:0043197 IDA dendritic spine
GO:0043235 ISO receptor complex
GO:0043236 IDA laminin binding
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045121 IEA membrane raft
GO:0045202 IDA synapse
GO:0045214 IMP sarcomere organization
GO:0045596 IMP negative regulation of cell differentiation
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045807 IEA positive regulation of endocytosis
GO:0046872 IEA metal ion binding
GO:0046982 ISS protein heterodimerization activity
GO:0048333 IEA mesodermal cell differentiation
GO:0048675 IGI axon extension
GO:0048738 IMP cardiac muscle tissue development
GO:0048813 IGI dendrite morphogenesis
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050839 IEA cell adhesion molecule binding
GO:0050901 IEA leukocyte tethering or rolling
GO:0051393 IEA alpha-actinin binding
GO:0051726 IMP regulation of cell cycle
GO:0055007 IMP cardiac muscle cell differentiation
GO:0060135 IEA maternal process involved in female pregnancy
GO:0070062 IEA extracellular vesicular exosome
GO:0070830 IEA tight junction assembly
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071305 IEA cellular response to vitamin D
GO:0071438 ISS invadopodium membrane
GO:0071479 IEA cellular response to ionizing radiation
GO:0071559 IEA response to transforming growth factor beta
GO:0090004 ISS positive regulation of establishment of protein localization to plasma membrane
GO:0097060 IDA synaptic membrane
GO:0098639 IEA collagen binding involved in cell-matrix adhesion
GO:2000811 IEA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022689 itgb1b.2 integrin, beta 1b.2 protein_coding Danio_rerio
ENSDARG00000053232 itgb1b.1 integrin, beta 1b.1 protein_coding Danio_rerio
ENSDARG00000053255 itgb1b integrin, beta 1b protein_coding Danio_rerio
ENSDARG00000071863 itgb1a integrin, beta 1a protein_coding Danio_rerio
ENSG00000150093 ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) protein_coding Homo_sapiens

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