C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: large tumor suppressor kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000150457 LATS2 9606 - 13:20973032-21061547 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000382592 LATS2-001 20973032-21061547 protein_coding
  ENST00000472754 LATS2-003 20989010-21023129 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000382592
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000382592 13.193±0.00 2.958±0.00 1.593±0.00 0.790±0.47 4.721±0.00 3.650±2.18 3.071±1.85 1.720±0.80 2.196±1.70 5.108±0.00 3.118±1.57 3.932±3.37 4.290±1.17 7.915±0.52

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003SQ CIL_0003SQ_0001 CGP 13:20777329-21061547
CIL_0003SR CIL_0003SR_0001 CGP 13:20973032-21149084

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0000922 IDA spindle pole
GO:0004672 IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0007067 IEA mitotic nuclear division
GO:0009755 IDA hormone-mediated signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030216 IEA keratinocyte differentiation
GO:0034613 IEA cellular protein localization
GO:0035329 IDA hippo signaling
GO:0035556 IDA intracellular signal transduction
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0046620 IEA regulation of organ growth
GO:0046872 IEA metal ion binding
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078864 lats2 LATS, large tumor suppressor, homolog 2 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000021959 Lats2 large tumor suppressor 2 protein_coding Mus_musculus

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