C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein tyrosine phosphatase, receptor type, O
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000151490 PTPRO 9606 + 12:15322397-15597399 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000281171 PTPRO-001 15322397-15597393 protein_coding
  ENST00000348962 PTPRO-002 15322553-15597393 protein_coding
  ENST00000442921 PTPRO-004 15546352-15597399 protein_coding
  ENST00000445537 PTPRO-006 15546352-15597399 protein_coding
  ENST00000535311 PTPRO-011 15546618-15580069 nonsense_mediated_decay
  ENST00000535322 PTPRO-012 15580763-15587176 protein_coding
  ENST00000538907 PTPRO-009 15565349-15580746 retained_intron
  ENST00000542557 PTPRO-005 15546352-15597399 protein_coding
  ENST00000543886 PTPRO-003 15322543-15517063 protein_coding
  ENST00000544244 PTPRO-007 15546352-15597399 protein_coding
  ENST00000544706 PTPRO-010 15595221-15596574 processed_transcript
  ENST00000545023 PTPRO-008 15322777-15410766 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENST00000281171ENST00000348962ENST00000442921ENST00000445537ENST00000535311ENST00000535322ENST00000538907ENST00000542557ENST00000543886ENST00000544244ENST00000544706
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000281171 N/A N/A N/A 2.164±1.09 N/A N/A 1.161±0.00 N/A N/A N/A N/A N/A N/A
ENST00000348962 N/A N/A 2.989±0.00 1.101±0.00 N/A 0.141±0.00 5.641±0.00 N/A N/A N/A N/A N/A N/A
ENST00000442921 N/A 0.294±0.00 N/A N/A N/A 1.218±0.00 N/A N/A N/A N/A 0.520±0.14 0.253±0.00 0.320±0.00
ENST00000445537 N/A 0.333±0.00 0.726±0.00 N/A N/A N/A N/A N/A N/A N/A 0.772±0.65 0.145±0.00 N/A
ENST00000535311 N/A N/A N/A N/A N/A N/A 0.756±0.00 N/A N/A N/A N/A N/A N/A
ENST00000535322 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.250±0.00 N/A N/A N/A
ENST00000538907 N/A N/A N/A N/A 1.811±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000542557 0.405±0.00 N/A N/A N/A 0.355±0.03 0.376±0.00 N/A 0.161±0.01 0.907±0.00 0.082±0.00 0.679±0.56 1.072±0.36 0.262±0.00
ENST00000543886 N/A N/A N/A N/A N/A N/A N/A 0.139±0.00 N/A 0.058±0.00 N/A N/A N/A
ENST00000544244 0.161±0.00 N/A N/A 0.652±0.00 N/A 0.149±0.00 0.808±0.53 N/A N/A N/A 0.667±0.00 0.199±0.05 N/A
ENST00000544706 N/A N/A N/A N/A N/A N/A 0.862±0.00 0.167±0.00 N/A 0.256±0.00 0.561±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000374 CIL_000374_0001 CGP 12:14973022-15348675
CIL_000375 CIL_000375_0001 CGP 12:15107783-15597399
CIL_0005VB CIL_0005VB_0002 CGP 12:15322397-15882329

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 ISS cell morphogenesis
GO:0002548 IMP monocyte chemotaxis
GO:0003093 ISS regulation of glomerular filtration
GO:0003105 ISS negative regulation of glomerular filtration
GO:0004725 TAS:IEA protein tyrosine phosphatase activity
GO:0005001 NAS transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 IPI:IEA protein binding
GO:0005886 ISS plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0006470 ISS:IEA protein dephosphorylation
GO:0007411 ISS axon guidance
GO:0010812 ISS negative regulation of cell-substrate adhesion
GO:0010977 ISS negative regulation of neuron projection development
GO:0016021 TAS integral component of membrane
GO:0016311 IEA dephosphorylation
GO:0016324 ISS apical plasma membrane
GO:0016328 ISS lateral plasma membrane
GO:0016791 ISS:IEA phosphatase activity
GO:0017147 ISS Wnt-protein binding
GO:0030027 ISS lamellipodium
GO:0030032 ISS lamellipodium assembly
GO:0030424 ISS axon
GO:0030426 ISS growth cone
GO:0032835 IMP glomerulus development
GO:0035335 IMP peptidyl-tyrosine dephosphorylation
GO:0036060 ISS slit diaphragm assembly
GO:0042803 ISS protein homodimerization activity
GO:0043005 ISS neuron projection
GO:0043197 ISS dendritic spine
GO:0070062 IDA extracellular vesicular exosome
GO:0072112 ISS glomerular visceral epithelial cell differentiation
GO:0090090 ISS negative regulation of canonical Wnt signaling pathway
GO:0090260 ISS negative regulation of retinal ganglion cell axon guidance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022297 ptpro protein tyrosine phosphatase, receptor type, O protein_coding Danio_rerio
ENSMUSG00000030223 Ptpro protein tyrosine phosphatase, receptor type, O protein_coding Mus_musculus

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