C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: X-ray repair complementing defective repair in Chinese hamster cells 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000152422 XRCC4 9606 + 5:83077498-83353787 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282268 XRCC4-201 83077498-83353758 protein_coding
  ENST00000338635 XRCC4-002 83077527-83353711 protein_coding
  ENST00000396027 XRCC4-001 83077570-83353711 protein_coding
  ENST00000509268 XRCC4-005 83104908-83259339 processed_transcript
  ENST00000511817 XRCC4-003 83077593-83353787 protein_coding
  ENST00000542685 XRCC4-004 83077557-83311069 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000282268ENST00000338635ENST00000396027ENST00000509268ENST00000511817ENST00000542685
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000282268 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.105±0.00 N/A 0.218±0.00 N/A
ENST00000338635 1.083±0.00 0.967±0.00 N/A 0.473±0.00 1.302±0.24 1.031±0.56 1.276±0.00 1.641±0.00 0.563±0.00 0.999±0.00 N/A 0.317±0.00 0.402±0.00 2.170±1.06
ENST00000396027 0.359±0.00 N/A N/A 0.465±0.00 N/A 0.753±0.00 0.078±0.00 0.179±0.00 0.223±0.00 N/A 0.223±0.00 1.822±1.09 1.344±0.98 5.257±0.00
ENST00000509268 N/A N/A 0.456±0.00 N/A 1.718±0.00 N/A 0.135±0.00 N/A N/A N/A N/A 0.372±0.00 N/A N/A
ENST00000511817 N/A 0.308±0.00 N/A 0.367±0.08 0.441±0.00 N/A 0.379±0.00 0.929±0.00 0.205±0.00 N/A N/A 0.274±0.00 N/A 0.913±0.19
ENST00000542685 0.898±0.00 0.883±0.00 0.048±0.00 0.973±0.00 N/A 0.577±0.00 0.300±0.09 0.150±0.00 0.610±0.32 0.235±0.00 N/A 0.948±0.28 0.267±0.09 1.028±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005TL CIL_0005TL_0002 CGP 5:83052846-83353787

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0002328 IEA pro-B cell differentiation
GO:0003677 IEA DNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005813 IDA centrosome
GO:0005829 IDA cytosol
GO:0005958 IDA DNA-dependent protein kinase-DNA ligase 4 complex
GO:0006266 IEA DNA ligation
GO:0006281 TAS DNA repair
GO:0006302 IDA:IEA double-strand break repair
GO:0006303 IDA double-strand break repair via nonhomologous end joining
GO:0006310 IEA DNA recombination
GO:0007417 IEA central nervous system development
GO:0008022 IPI protein C-terminus binding
GO:0010165 IDA response to X-ray
GO:0010212 IEA response to ionizing radiation
GO:0010332 IEA response to gamma radiation
GO:0016032 TAS viral process
GO:0030054 IDA cell junction
GO:0032807 IDA DNA ligase IV complex
GO:0033077 IEA T cell differentiation in thymus
GO:0033151 IEA V(D)J recombination
GO:0033152 IEA immunoglobulin V(D)J recombination
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045190 IEA isotype switching
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0050769 IEA positive regulation of neurogenesis
GO:0051103 IDA DNA ligation involved in DNA repair
GO:0051351 IDA positive regulation of ligase activity
GO:0070419 IDA nonhomologous end joining complex
GO:0071285 IEA cellular response to lithium ion
GO:0075713 TAS establishment of integrated proviral latency

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010732 xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 protein_coding Danio_rerio
ENSMUSG00000021615 Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 protein_coding Mus_musculus

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