C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000154277 UCHL1 9606 + 4:41256413-41268455 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000284440 UCHL1-001 41256833-41268429 protein_coding
  ENST00000381760 UCHL1-003 41256908-41268428 retained_intron
  ENST00000472501 UCHL1-004 41256946-41268427 retained_intron
  ENST00000503431 UCHL1-005 41256769-41268256 protein_coding
  ENST00000504818 UCHL1-011 41256933-41261923 processed_transcript
  ENST00000505232 UCHL1-010 41256932-41268108 nonsense_mediated_decay
  ENST00000508768 UCHL1-009 41256940-41268239 protein_coding
  ENST00000510566 UCHL1-008 41261739-41264465 retained_intron
  ENST00000512419 UCHL1-002 41256911-41268455 nonsense_mediated_decay
  ENST00000512788 UCHL1-012 41256945-41268125 protein_coding
  ENST00000514764 UCHL1-006 41260639-41268429 retained_intron
  ENST00000514924 UCHL1-007 41256413-41257737 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000284440ENST00000381760ENST00000472501ENST00000503431ENST00000504818ENST00000505232ENST00000508768ENST00000512419ENST00000514764
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000284440 1.240±0.00 N/A 1.422±0.00 139.140±0.00 8.522±5.79 N/A 0.116±0.00 N/A 0.735±0.57 N/A N/A 9.719±8.97 4.221±0.00 6.497±0.00
ENST00000381760 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.109±0.00
ENST00000472501 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.792±0.00 N/A N/A N/A N/A
ENST00000503431 6.903±0.00 3.345±0.00 0.461±0.00 226.074±177.75 53.510±0.00 14.916±11.79 1.926±0.00 55.728±0.00 N/A 3.017±0.00 1.716±0.00 4.259±4.44 3.231±1.57 10.469±4.42
ENST00000504818 N/A N/A N/A N/A N/A 1.160±0.00 N/A N/A 0.927±0.00 N/A N/A N/A N/A N/A
ENST00000505232 N/A N/A N/A N/A N/A 7.328±0.00 N/A N/A N/A N/A N/A 9.912±0.00 N/A N/A
ENST00000508768 N/A N/A 0.483±0.00 N/A N/A N/A N/A N/A 0.073±0.00 N/A N/A N/A N/A N/A
ENST00000512419 1.145±0.00 1.101±0.00 N/A N/A N/A N/A N/A N/A N/A 1.153±0.00 0.664±0.00 6.063±5.81 1.549±0.21 3.752±0.00
ENST00000514764 2.239±0.00 1.370±0.00 N/A 195.254±0.00 29.482±0.00 16.367±0.00 3.954±0.00 27.006±0.00 0.191±0.00 4.525±0.00 1.633±0.99 23.767±8.81 5.362±2.32 8.386±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00038S CIL_00038S_0001 CGP 4:40810027-41268455
CIL_00038J CIL_00038J_0001 CGP 4:41256413-41700044

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002931 IEA response to ischemia
GO:0004197 IDA cysteine-type endopeptidase activity
GO:0004221 TAS ubiquitin thiolesterase activity
GO:0004843 IEA ubiquitin-specific protease activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005829 IEA cytosol
GO:0005886 IDA plasma membrane
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0007409 IEA axonogenesis
GO:0007412 IEA axon target recognition
GO:0007628 IEA adult walking behavior
GO:0008219 IEA cell death
GO:0008242 IDA omega peptidase activity
GO:0008283 IEA cell proliferation
GO:0016579 IDA protein deubiquitination
GO:0016874 IEA ligase activity
GO:0019233 IEA sensory perception of pain
GO:0019896 IEA axon transport of mitochondrion
GO:0030424 IEA axon
GO:0031694 IPI alpha-2A adrenergic receptor binding
GO:0042755 IEA eating behavior
GO:0043025 IEA neuronal cell body
GO:0043130 IDA ubiquitin binding
GO:0043161 NAS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043407 IDA negative regulation of MAP kinase activity
GO:0048747 IEA muscle fiber development
GO:0050905 IEA neuromuscular process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026871 uchl1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) protein_coding Danio_rerio
ENSMUSG00000029223 Uchl1 ubiquitin carboxy-terminal hydrolase L1 protein_coding Mus_musculus

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