C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000338785 DYRK1A-001 ENSG00000157540 9606 + 21:37367577-37515377 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000338785
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000338785 2.913±0.00 7.071±0.00 6.617±0.00 4.186±0.00 3.467±0.00 1.799±0.00 4.832±1.25 7.563±0.00 1.966±0.00 9.132±4.94 6.289±1.71 9.419±6.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CZ CIL_0001CZ_0002 CGP 21:37223420-37517450
CIL_0006ZG CIL_0006ZG_0001 CGP 21:37365790-37916446

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000278 TAS mitotic cell cycle
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004712 IEA protein serine/threonine/tyrosine kinase activity
GO:0004713 ISS:IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0006468 ISS:IEA protein phosphorylation
GO:0007399 TAS nervous system development
GO:0007623 ISS circadian rhythm
GO:0016607 ISS nuclear speck
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 ISS peptidyl-threonine phosphorylation
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0043518 ISS negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043621 ISS protein self-association
GO:0046777 ISS protein autophosphorylation
GO:0048156 ISS tau protein binding
GO:0090312 ISS positive regulation of protein deacetylation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000023614 Dyrk1a-201 protein_coding Mus_musculus 0 3530
ENSMUST00000119878 Dyrk1a-001 protein_coding Mus_musculus 0 3530
ENSMUST00000122284 Dyrk1a-002 protein_coding Mus_musculus 0 2106
ENSMUST00000155791 Dyrk1a-004 protein_coding Mus_musculus 0 970
ENSMUST00000134383 Dyrk1a-005 retained_intron Mus_musculus 0 959
ENSDART00000100073 dyrk1aa-201 protein_coding Danio_rerio 0 780
ENSDART00000038748 dyrk1b-001 protein_coding Danio_rerio 0 525
ENSMUST00000139250 Dyrk1a-003 protein_coding Mus_musculus 0 466
ENSDART00000144722 dyrk1aa-002 protein_coding Danio_rerio 0 340
ENSDART00000141723 dyrk1aa-001 protein_coding Danio_rerio 0 322
ENSDART00000147674 dyrk1aa-004 processed_transcript Danio_rerio 6e-27 128

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