C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ISL LIM homeobox 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000159556 ISL2 9606 + 15:76336724-76342476 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000290759 ISL2-001 76336724-76342476 protein_coding
  ENST00000558437 ISL2-003 76337438-76338514 retained_intron
  ENST00000558656 ISL2-002 76336808-76342388 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonLungOvaryPlacentaTestisENST00000290759ENST00000558437ENST00000558656
Transcript ID Adipose Adrenal Brain Breast Colon Lung Ovary Placenta Testis
ENST00000290759 N/A N/A 0.038±0.00 0.145±0.00 0.290±0.13 0.136±0.00 0.145±0.00 N/A 0.558±0.35
ENST00000558437 0.032±0.00 0.034±0.00 N/A N/A N/A N/A N/A 0.070±0.00 0.822±0.00
ENST00000558656 N/A 0.021±0.00 N/A 0.023±0.00 0.201±0.01 N/A 0.281±0.23 0.040±0.00 0.186±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000248 CIL_000248_0001 CGP 15:76215355-76342476
CIL_000245 CIL_000245_0001 CGP 15:76336724-76905444

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 ISS:IEA DNA binding
GO:0005622 IEA intracellular
GO:0005634 IC nucleus
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0008270 IEA zinc ion binding
GO:0021520 IEA spinal cord motor neuron cell fate specification
GO:0021524 IEA visceral motor neuron differentiation
GO:0031290 IEA retinal ganglion cell axon guidance
GO:0043565 IEA sequence-specific DNA binding
GO:0045665 IEA negative regulation of neuron differentiation
GO:0048663 IEA neuron fate commitment
GO:0048666 TAS neuron development
GO:0048935 TAS peripheral nervous system neuron development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003971 isl2a islet2a protein_coding Danio_rerio
ENSDARG00000053499 isl2b islet2b protein_coding Danio_rerio
ENSMUSG00000032318 Isl2 insulin related protein 2 (islet 2) protein_coding Mus_musculus

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