C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NEDD8 activating enzyme E1 subunit 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000159593 NAE1 9606 - 16:66802875-66873256 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000290810 NAE1-001 66802875-66830997 protein_coding
  ENST00000359087 NAE1-002 66802875-66830976 protein_coding
  ENST00000379463 NAE1-005 66802880-66830976 protein_coding
  ENST00000394074 NAE1-004 66802912-66830955 protein_coding
  ENST00000561579 NAE1-010 66817470-66873256 protein_coding
  ENST00000562074 NAE1-008 66805630-66808694 retained_intron
  ENST00000562428 NAE1-018 66802875-66808548 protein_coding
  ENST00000562757 NAE1-016 66823342-66830976 retained_intron
  ENST00000563185 NAE1-014 66817434-66830973 protein_coding
  ENST00000563221 NAE1-017 66802880-66806069 retained_intron
  ENST00000563253 NAE1-013 66816647-66830959 nonsense_mediated_decay
  ENST00000563419 NAE1-006 66824516-66830960 retained_intron
  ENST00000564040 NAE1-022 66818633-66830963 processed_transcript
  ENST00000565535 NAE1-021 66823230-66830976 protein_coding
  ENST00000566336 NAE1-020 66821456-66830917 protein_coding
  ENST00000566663 NAE1-011 66802878-66810413 protein_coding
  ENST00000567521 NAE1-007 66813129-66816716 retained_intron
  ENST00000567743 NAE1-003 66816614-66830968 nonsense_mediated_decay
  ENST00000568672 NAE1-009 66802880-66806145 retained_intron
  ENST00000569348 NAE1-019 66823281-66830976 nonsense_mediated_decay
  ENST00000569388 NAE1-015 66821446-66830977 nonsense_mediated_decay
  ENST00000569963 NAE1-012 66826099-66830976 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000290810ENST00000379463ENST00000394074ENST00000563253ENST00000567743ENST00000568672
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000290810 3.634±0.00 0.864±0.00 5.639±0.00 N/A 2.181±0.76 2.098±0.00 N/A 2.485±1.44 N/A 2.924±0.00 8.657±4.72 4.365±0.62 11.475±3.32
ENST00000379463 N/A N/A N/A N/A N/A 1.355±0.00 N/A 1.348±0.00 N/A N/A N/A N/A N/A
ENST00000394074 7.672±0.00 0.853±0.00 7.412±4.38 6.467±0.00 7.336±0.00 1.796±0.00 7.501±0.00 4.459±0.00 2.049±0.25 2.298±0.00 3.770±2.24 4.356±0.18 18.469±0.00
ENST00000563253 N/A N/A N/A N/A N/A N/A 5.024±0.00 N/A N/A N/A N/A N/A N/A
ENST00000567743 N/A N/A N/A N/A N/A N/A N/A 1.955±0.00 2.915±0.00 N/A 1.667±0.00 N/A N/A
ENST00000568672 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.192±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007WN CIL_0007WN_0001 VISTA 16:66603173-67205657
CIL_0004IV CIL_0004IV_0001 CGP 16:66754976-66873256
CIL_0003LY CIL_0003LY_0002 CGP 16:66802875-66873256

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003824 IEA catalytic activity
GO:0005515 IPI protein binding
GO:0005634 IBA nucleus
GO:0005737 TAS cytoplasm
GO:0005829 IBA cytosol
GO:0005886 IEA plasma membrane
GO:0007165 TAS signal transduction
GO:0008152 IEA metabolic process
GO:0019781 IDA NEDD8 activating enzyme activity
GO:0031625 IPI ubiquitin protein ligase binding
GO:0033314 IDA mitotic DNA replication checkpoint
GO:0042981 IDA regulation of apoptotic process
GO:0043523 IDA regulation of neuron apoptotic process
GO:0045116 IEA protein neddylation
GO:0046982 IPI protein heterodimerization activity
GO:0051402 IDA neuron apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011301 nae1 nedd8 activating enzyme E1 subunit 1 protein_coding Danio_rerio
ENSMUSG00000031878 Nae1 NEDD8 activating enzyme E1 subunit 1 protein_coding Mus_musculus

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