C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cystathionine-beta-synthase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160200 CBS 9606 - 21:43053191-43076943 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000352178 CBS-001 43053191-43076378 protein_coding
  ENST00000359624 CBS-002 43053191-43076362 protein_coding
  ENST00000398158 CBS-004 43053191-43075831 protein_coding
  ENST00000398165 CBS-003 43053191-43075945 protein_coding
  ENST00000430013 CBS-014 43055598-43060546 protein_coding
  ENST00000441030 CBS-007 43065616-43076943 protein_coding
  ENST00000451248 CBS-016 43053755-43058941 protein_coding
  ENST00000458223 CBS-015 43055583-43058954 protein_coding
  ENST00000461686 CBS-005 43053191-43068404 retained_intron
  ENST00000462349 CBS-013 43053789-43059739 retained_intron
  ENST00000465732 CBS-009 43068321-43075864 processed_transcript
  ENST00000470912 CBS-008 43066243-43075945 processed_transcript
  ENST00000478709 CBS-017 43075107-43076288 processed_transcript
  ENST00000486098 CBS-012 43061919-43063248 retained_intron
  ENST00000488526 CBS-010 43068404-43073508 processed_transcript
  ENST00000491776 CBS-006 43055072-43060520 retained_intron
  ENST00000496485 CBS-011 43059276-43064227 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359624ENST00000398158ENST00000441030ENST00000461686ENST00000462349ENST00000465732ENST00000470912ENST00000478709ENST00000486098ENST00000488526ENST00000491776ENST00000496485
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359624 N/A N/A N/A N/A 0.012±0.00 0.037±0.00 N/A 0.182±0.00 0.048±0.00 0.255±0.00 0.028±0.00 N/A 0.064±0.00 0.084±0.00
ENST00000398158 N/A N/A 0.022±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.385±0.00 0.032±0.00 N/A
ENST00000441030 N/A N/A N/A 1.004±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000461686 0.042±0.00 N/A N/A N/A N/A N/A 0.017±0.00 2.655±0.00 N/A N/A N/A 0.809±0.45 0.073±0.00 0.084±0.00
ENST00000462349 0.288±0.00 N/A 0.066±0.00 0.633±0.37 0.034±0.00 N/A 0.029±0.00 N/A 0.551±0.32 0.326±0.00 N/A 1.525±0.92 N/A 0.264±0.00
ENST00000465732 N/A N/A N/A N/A 0.512±0.00 N/A 0.094±0.02 0.548±0.00 N/A N/A N/A 1.797±0.00 N/A N/A
ENST00000470912 N/A N/A N/A N/A N/A N/A 0.085±0.00 N/A N/A 0.279±0.00 N/A N/A N/A N/A
ENST00000478709 N/A 0.125±0.00 N/A 2.381±0.00 0.345±0.00 0.137±0.00 N/A N/A 0.463±0.31 N/A N/A 0.767±0.00 0.219±0.11 N/A
ENST00000486098 N/A 0.189±0.00 N/A N/A N/A 0.195±0.00 N/A N/A 0.213±0.00 0.106±0.00 N/A N/A 0.067±0.00 N/A
ENST00000488526 N/A N/A N/A 0.820±0.09 0.035±0.00 N/A N/A N/A N/A N/A 0.251±0.00 N/A N/A N/A
ENST00000491776 0.124±0.00 0.101±0.00 N/A 0.609±0.13 0.088±0.00 0.086±0.00 0.015±0.00 0.504±0.33 0.324±0.00 0.134±0.01 N/A 1.366±1.28 0.065±0.02 0.171±0.10
ENST00000496485 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.085±0.03 0.204±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000D3 CIL_0000D3_0001 CGP 21:42974510-43076943
CIL_0000MQ CIL_0000MQ_0002 CGP 21:43053191-43107587

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000096 TAS sulfur amino acid metabolic process
GO:0004122 IDA:IEA cystathionine beta-synthase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0006535 IEA cysteine biosynthetic process from serine
GO:0006563 IDA L-serine metabolic process
GO:0006565 IDA L-serine catabolic process
GO:0019343 IEA cysteine biosynthetic process via cystathionine
GO:0019346 TAS transsulfuration
GO:0019448 IDA L-cysteine catabolic process
GO:0019899 IPI enzyme binding
GO:0020037 IMP heme binding
GO:0030170 IDA pyridoxal phosphate binding
GO:0030554 IEA adenyl nucleotide binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043418 IDA homocysteine catabolic process
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0050667 IDA homocysteine metabolic process
GO:0070814 ISS hydrogen sulfide biosynthetic process
GO:0072341 IDA modified amino acid binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010946 cbsb cystathionine-beta-synthase b protein_coding Danio_rerio
ENSDARG00000053500 cbsa cystathionine-beta-synthase a protein_coding Danio_rerio
ENSMUSG00000024039 Cbs cystathionine beta-synthase protein_coding Mus_musculus

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