C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lamin A/C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160789 LMNA 9606 + 1:156082573-156140089 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000347559 LMNA-201 156114670-156140089 protein_coding
  ENST00000361308 LMNA-202 156114670-156137764 protein_coding
  ENST00000368297 LMNA-007 156126189-156137865 protein_coding
  ENST00000368298 LMNA-018 156135113-156137267 retained_intron
  ENST00000368299 LMNA-004 156114722-156139317 protein_coding
  ENST00000368300 LMNA-001 156114707-156140089 protein_coding
  ENST00000368301 LMNA-002 156082578-156137865 protein_coding
  ENST00000448611 LMNA-017 156126160-156140013 protein_coding
  ENST00000459904 LMNA-015 156136293-156137292 processed_transcript
  ENST00000469565 LMNA-025 156114713-156134446 processed_transcript
  ENST00000470199 LMNA-023 156114711-156134498 processed_transcript
  ENST00000470835 LMNA-013 156082631-156093811 processed_transcript
  ENST00000473598 LMNA-006 156126555-156139303 protein_coding
  ENST00000478063 LMNA-024 156114711-156115047 processed_transcript
  ENST00000495341 LMNA-010 156082600-156083613 processed_transcript
  ENST00000496738 LMNA-005 156134821-156139303 processed_transcript
  ENST00000498722 LMNA-019 156135733-156138161 retained_intron
  ENST00000502357 LMNA-026 156123142-156134528 processed_transcript
  ENST00000502751 LMNA-021 156082573-156134487 processed_transcript
  ENST00000504687 LMNA-028 156126545-156134960 protein_coding
  ENST00000506981 LMNA-030 156137462-156139103 retained_intron
  ENST00000508500 LMNA-020 156136087-156139171 protein_coding
  ENST00000515459 LMNA-027 156126174-156135225 nonsense_mediated_decay
  ENST00000515711 LMNA-022 156106658-156114838 processed_transcript
  ENST00000515824 LMNA-029 156134805-156135408 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000347559ENST00000361308ENST00000368297ENST00000368299ENST00000368300ENST00000448611ENST00000496738ENST00000498722ENST00000504687ENST00000508500
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000347559 N/A N/A N/A N/A N/A N/A 1.967±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000361308 91.910±0.00 79.567±0.00 N/A 20.846±0.00 113.046±0.00 39.288±0.00 36.170±0.00 48.823±0.00 20.893±0.00 91.000±0.00 54.549±0.00 689.989±0.00 85.162±48.72 48.288±8.11
ENST00000368297 N/A N/A N/A 1.981±0.00 7.428±0.00 12.425±0.00 4.564±0.00 4.881±0.00 N/A N/A N/A 67.694±41.53 N/A 11.431±0.00
ENST00000368299 N/A N/A 2.329±0.00 3.747±0.00 17.472±0.00 22.583±0.00 8.858±1.90 4.071±0.00 13.878±0.00 11.326±0.00 22.056±5.47 86.664±34.88 61.449±20.17 N/A
ENST00000368300 61.716±0.00 41.127±0.00 N/A 10.229±0.00 37.267±30.34 21.042±12.63 8.501±6.02 33.217±0.00 12.302±2.59 50.729±45.58 38.923±0.00 102.487±65.30 52.140±22.19 18.416±0.00
ENST00000448611 N/A N/A N/A 10.062±0.00 N/A N/A N/A 16.224±14.41 9.932±0.00 60.311±0.00 5.113±0.00 113.185±0.00 N/A 26.078±10.27
ENST00000496738 N/A N/A 8.006±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 118.408±0.00 N/A N/A
ENST00000498722 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 349.764±0.00 80.821±0.00 22.286±0.00
ENST00000504687 N/A N/A 12.949±0.00 N/A 32.319±0.00 N/A N/A N/A 47.453±0.00 18.984±0.00 N/A 77.944±0.00 N/A N/A
ENST00000508500 N/A N/A N/A N/A N/A N/A 24.154±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000898 CIL_000898_0001 VISTA 1:155789635-156392759
CIL_0008P5 CIL_0008P5_0001 VISTA 1:155795688-156399252

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000278 TAS mitotic cell cycle
GO:0005198 IEA structural molecule activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005635 IDA nuclear envelope
GO:0005638 TAS lamin filament
GO:0005652 TAS nuclear lamina
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005882 TAS:IEA intermediate filament
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0006997 IEA nucleus organization
GO:0006998 IEA nuclear envelope organization
GO:0007077 TAS mitotic nuclear envelope disassembly
GO:0007084 TAS mitotic nuclear envelope reassembly
GO:0007517 IMP muscle organ development
GO:0030334 ISS regulation of cell migration
GO:0030951 ISS establishment or maintenance of microtubule cytoskeleton polarity
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0034504 ISS protein localization to nucleus
GO:0035105 IEA sterol regulatory element binding protein import into nucleus
GO:0044267 TAS cellular protein metabolic process
GO:0048471 IDA perinuclear region of cytoplasm
GO:0055015 IEA ventricular cardiac muscle cell development
GO:0071456 IEP cellular response to hypoxia
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:0090343 IDA positive regulation of cell aging
GO:1900180 IEA regulation of protein localization to nucleus
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013415 lmna lamin A protein_coding Danio_rerio
ENSMUSG00000028063 Lmna lamin A protein_coding Mus_musculus

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