C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, ATPase, 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000161057 PSMC2 9606 + 7:103344254-103369395 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000292644 PSMC2-201 103347712-103369389 protein_coding
  ENST00000425206 PSMC2-002 103344266-103362057 protein_coding
  ENST00000435765 PSMC2-001 103344914-103369395 protein_coding
  ENST00000457587 PSMC2-003 103344254-103362057 protein_coding
  ENST00000460021 PSMC2-004 103353919-103362467 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000292644ENST00000425206
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000292644 14.799±0.00 10.281±0.00 8.803±0.00 12.027±5.22 11.066±5.25 9.861±3.80 8.035±4.67 14.310±6.03 8.090±4.59 7.102±0.40 13.638±6.41 12.612±4.00 4.891±1.74 6.807±3.47
ENST00000425206 N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.072±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001RL CIL_0001RL_0002 CGP 7:103297422-103344873
CIL_0005C8 CIL_0005C8_0001 CGP 7:103312474-103369395
CIL_0001RC CIL_0001RC_0002 CGP 7:103344254-103446177

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0000932 ISS cytoplasmic mRNA processing body
GO:0001649 IDA osteoblast differentiation
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 TAS:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006200 IDA ATP catabolic process
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016787 IEA hydrolase activity
GO:0016887 IDA ATPase activity
GO:0022624 ISS proteasome accessory complex
GO:0030163 IEA protein catabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020101 psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 protein_coding Danio_rerio
ENSMUSG00000028932 Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 protein_coding Mus_musculus

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