C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000161638 ITGA5 9606 - 12:54395261-54419460 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293379 ITGA5-001 54395261-54419460 protein_coding
  ENST00000435631 ITGA5-002 54404771-54419220 nonsense_mediated_decay
  ENST00000547197 ITGA5-012 54395895-54399913 protein_coding
  ENST00000547744 ITGA5-005 54411908-54413428 processed_transcript
  ENST00000549601 ITGA5-010 54396222-54398823 retained_intron
  ENST00000550141 ITGA5-007 54403632-54404344 retained_intron
  ENST00000551564 ITGA5-008 54402081-54403172 retained_intron
  ENST00000551861 ITGA5-006 54403916-54404629 retained_intron
  ENST00000552387 ITGA5-013 54397366-54400858 retained_intron
  ENST00000552431 ITGA5-011 54397271-54399913 retained_intron
  ENST00000552564 ITGA5-004 54395261-54406116 retained_intron
  ENST00000552583 ITGA5-009 54401560-54402272 retained_intron
  ENST00000553071 ITGA5-003 54405194-54419127 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000293379ENST00000550141ENST00000552387ENST00000552564
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000293379 41.031±0.00 36.868±0.00 0.973±0.00 2.650±2.30 11.762±6.05 28.705±25.23 9.219±6.97 9.119±5.48 18.883±9.85 62.113±56.50 6.993±4.94 16.472±8.78 138.837±52.44 8.459±7.58
ENST00000550141 N/A N/A N/A 0.905±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000552387 N/A N/A N/A 0.242±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000552564 N/A N/A 0.201±0.00 N/A 1.587±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.355±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000031 CIL_000031_0001 CGP 12:54369133-54419460
CIL_00003E CIL_00003E_0001 CGP 12:54395261-54473602

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 TAS angiogenesis
GO:0001726 TAS ruffle
GO:0005154 IEA epidermal growth factor receptor binding
GO:0005161 TAS platelet-derived growth factor receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0007044 IEA cell-substrate junction assembly
GO:0007155 TAS cell adhesion
GO:0007157 IEA heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 IEA leukocyte cell-cell adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0007613 IEA memory
GO:0008305 IEA integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010811 IEA positive regulation of cell-substrate adhesion
GO:0016032 IEA viral process
GO:0030198 TAS extracellular matrix organization
GO:0030335 IEA positive regulation of cell migration
GO:0030949 TAS positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589 IMP cell-substrate adhesion
GO:0032587 IDA ruffle membrane
GO:0033631 IEA cell-cell adhesion mediated by integrin
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0035313 IEP wound healing, spreading of epidermal cells
GO:0035987 IMP endodermal cell differentiation
GO:0043184 TAS vascular endothelial growth factor receptor 2 binding
GO:0045202 IEA synapse
GO:0046872 IEA metal ion binding
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050839 IEA cell adhesion molecule binding
GO:0050900 TAS leukocyte migration
GO:0071062 TAS alphav-beta3 integrin-vitronectin complex
GO:2000811 IMP negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006353 itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) protein_coding Danio_rerio
ENSMUSG00000000555 Itga5 integrin alpha 5 (fibronectin receptor alpha) protein_coding Mus_musculus

Loading