C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NLR family, pyrin domain containing 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000162711 NLRP3 9606 + 1:247416156-247449108 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000336119 NLRP3-001 247418049-247448817 protein_coding
  ENST00000348069 NLRP3-002 247418049-247448817 protein_coding
  ENST00000366496 NLRP3-007 247418052-247448817 protein_coding
  ENST00000366497 NLRP3-201 247416156-247449102 protein_coding
  ENST00000391827 NLRP3-004 247418795-247448504 protein_coding
  ENST00000391828 NLRP3-003 247416156-247449108 protein_coding
  ENST00000474792 NLRP3-005 247418620-247425792 processed_transcript
  ENST00000532083 NLRP3-006 247443907-247448576 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000336119ENST00000348069ENST00000366497ENST00000391827ENST00000391828ENST00000474792ENST00000532083
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000336119 1.253±0.00 0.305±0.00 N/A N/A 0.440±0.00 N/A 0.203±0.00 0.154±0.00 N/A 0.969±0.00 N/A 0.152±0.10 0.368±0.03 N/A
ENST00000348069 N/A N/A N/A 0.555±0.00 N/A N/A N/A N/A 0.280±0.18 0.470±0.02 0.178±0.00 N/A N/A 0.094±0.00
ENST00000366497 N/A 0.154±0.00 N/A 0.166±0.00 N/A N/A N/A N/A N/A 0.307±0.00 N/A 0.175±0.00 N/A N/A
ENST00000391827 0.400±0.00 N/A N/A N/A N/A 0.036±0.00 N/A 0.231±0.00 N/A N/A N/A 0.141±0.09 N/A N/A
ENST00000391828 0.363±0.00 0.339±0.00 N/A 0.300±0.00 0.470±0.15 0.231±0.00 0.135±0.00 0.260±0.00 N/A 0.515±0.00 N/A 0.342±0.09 0.635±0.18 0.146±0.04
ENST00000474792 N/A N/A 0.110±0.00 N/A 0.746±0.00 N/A N/A N/A N/A N/A 0.020±0.00 0.443±0.00 N/A N/A
ENST00000532083 N/A 1.198±0.00 N/A 1.425±0.00 N/A N/A N/A N/A N/A 3.055±0.00 N/A 0.254±0.00 1.455±0.28 0.426±0.13

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006TS CIL_0006TS_0001 CGP 1:247297412-247449108
CIL_0006TJ CIL_0006TJ_0001 CGP 1:247416156-247451982

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002674 IMP negative regulation of acute inflammatory response
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0006915 NAS apoptotic process
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952 TAS defense response
GO:0006954 IMP inflammatory response
GO:0007165 NAS signal transduction
GO:0009595 TAS detection of biotic stimulus
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032611 IEA interleukin-1 beta production
GO:0032621 IEA interleukin-18 production
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042347 IDA negative regulation of NF-kappaB import into nucleus
GO:0042834 TAS peptidoglycan binding
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044546 IEA NLRP3 inflammasome complex assembly
GO:0045087 TAS innate immune response
GO:0050701 IEA interleukin-1 secretion
GO:0050713 IMP negative regulation of interleukin-1 beta secretion
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0050727 IEA regulation of inflammatory response
GO:0050728 IMP negative regulation of inflammatory response
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051259 TAS protein oligomerization
GO:0051607 IEA defense response to virus
GO:0071222 IMP cellular response to lipopolysaccharide
GO:0072559 IDA NLRP3 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000032691 Nlrp3 NLR family, pyrin domain containing 3 protein_coding Mus_musculus

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