C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NLR family, pyrin domain containing 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032691 Nlrp3 10090 + 11:59541568-59566956 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000079476 Nlrp3-001 59541568-59566955 protein_coding
  ENSMUST00000101148 Nlrp3-201 59542686-59566956 protein_coding
  ENSMUST00000149126 Nlrp3-002 59542756-59548118 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000079476ENSMUST00000101148
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000079476 0.215±0.07 0.191±0.06 0.113±0.03 0.130±0.04 0.350±0.01 0.149±0.05 0.125±0.03 0.169±0.04 0.226±0.11 0.490±0.05 0.014±0.00 0.443±0.09 0.097±0.03 0.036±0.02
ENSMUST00000101148 N/A N/A 0.124±0.06 N/A 0.316±0.19 N/A N/A 0.190±0.00 0.285±0.12 0.616±0.29 0.033±0.00 0.431±0.11 0.081±0.06 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006TS CIL_0006TS_0002 CGP 11:59485520-59566956
CIL_0006TJ CIL_0006TJ_0002 CGP 11:59541568-59571738

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002674 IEA negative regulation of acute inflammatory response
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 ISS inflammatory response
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0032611 IMP interleukin-1 beta production
GO:0032621 IMP interleukin-18 production
GO:0042347 ISS negative regulation of NF-kappaB import into nucleus
GO:0043280 ISS positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044546 IMP NLRP3 inflammasome complex assembly
GO:0050701 IMP interleukin-1 secretion
GO:0050713 IEA negative regulation of interleukin-1 beta secretion
GO:0050718 IGI:ISS positive regulation of interleukin-1 beta secretion
GO:0050727 IMP regulation of inflammatory response
GO:0050728 IEA negative regulation of inflammatory response
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051607 IMP defense response to virus
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0072559 ISS NLRP3 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000162711 NLRP3 NLR family, pyrin domain containing 3 protein_coding Homo_sapiens

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