C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: NLR family, pyrin domain containing 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000348069 NLRP3-002 ENSG00000162711 9606 + 1:247418049-247448817 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainLiverLungMuscleTestisENST00000348069
Transcript ID Brain Liver Lung Muscle Testis
ENST00000348069 0.555±0.00 0.280±0.18 0.470±0.02 0.178±0.00 0.094±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006TS CIL_0006TS_0001 CGP 1:247297412-247449108
CIL_0006TJ CIL_0006TJ_0001 CGP 1:247416156-247451982

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002674 IMP negative regulation of acute inflammatory response
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0006915 NAS apoptotic process
GO:0006952 TAS defense response
GO:0006954 IMP inflammatory response
GO:0007165 NAS signal transduction
GO:0009595 TAS detection of biotic stimulus
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042347 IDA negative regulation of NF-kappaB import into nucleus
GO:0042834 TAS peptidoglycan binding
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 TAS innate immune response
GO:0050713 IMP negative regulation of interleukin-1 beta secretion
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0050728 IMP negative regulation of inflammatory response
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051259 TAS protein oligomerization
GO:0071222 IMP cellular response to lipopolysaccharide
GO:0072559 IDA NLRP3 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000101148 Nlrp3-201 protein_coding Mus_musculus 0 1714
ENSMUST00000079476 Nlrp3-001 protein_coding Mus_musculus 0 1714

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