C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cathepsin S
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163131 CTSS 9606 - 1:150730196-150765957 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000368985 CTSS-001 150730196-150765957 protein_coding
  ENST00000448301 CTSS-006 150732567-150765792 protein_coding
  ENST00000472977 CTSS-004 150730882-150750091 nonsense_mediated_decay
  ENST00000480760 CTSS-002 150747796-150764702 processed_transcript
  ENST00000483930 CTSS-003 150732838-150751834 nonsense_mediated_decay
  ENST00000607427 CTSS-005 150730886-150733062 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000368985ENST00000448301ENST00000480760
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000368985 9.478±0.00 18.824±0.00 0.223±0.00 0.893±0.49 2.866±0.03 3.821±0.92 0.797±0.58 3.317±0.38 3.159±1.26 13.405±4.45 0.587±0.00 2.934±1.39 4.804±1.63 N/A
ENST00000448301 20.316±0.00 27.432±0.00 1.560±0.00 3.075±0.81 26.944±9.68 17.269±6.81 4.697±1.14 15.242±7.21 11.521±0.47 76.733±8.49 1.109±0.43 11.884±3.01 18.679±7.60 5.797±0.00
ENST00000480760 N/A N/A 4.621±0.00 2.964±1.29 22.192±0.00 35.464±0.00 2.996±0.00 17.041±0.00 17.454±0.00 74.834±0.00 1.571±0.00 19.966±10.80 22.816±5.98 0.559±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001968 IPI fibronectin binding
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002250 IEP adaptive immune response
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002480 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0004197 IDA cysteine-type endopeptidase activity
GO:0005518 IDA collagen binding
GO:0005576 NAS extracellular region
GO:0005615 IDA extracellular space
GO:0005764 IDA lysosome
GO:0006508 TAS:IEA proteolysis
GO:0006955 TAS immune response
GO:0008233 IEA peptidase activity
GO:0008234 IEA cysteine-type peptidase activity
GO:0016020 IEA membrane
GO:0019882 TAS antigen processing and presentation
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0030574 IDA collagen catabolic process
GO:0034769 IDA basement membrane disassembly
GO:0036021 TAS endolysosome lumen
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0043202 TAS lysosomal lumen
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043236 IDA laminin binding
GO:0043394 IPI proteoglycan binding
GO:0045087 TAS innate immune response
GO:0050729 IEA positive regulation of inflammatory response
GO:0051603 IDA proteolysis involved in cellular protein catabolic process
GO:0097067 IEP cellular response to thyroid hormone stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013771 ctssb.2 cathepsin Sb, tandem duplicate 2 protein_coding Danio_rerio
ENSDARG00000074656 ctssb.1 cathepsin Sb, tandem duplicate 1 protein_coding Danio_rerio
ENSMUSG00000038642 Ctss cathepsin S protein_coding Mus_musculus

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