C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cathepsin B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164733 CTSB 9606 - 8:11842524-11869448 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000345125 CTSB-007 11844340-11868079 protein_coding
  ENST00000353047 CTSB-001 11842524-11868229 protein_coding
  ENST00000420692 CTSB-041 11844020-11848703 retained_intron
  ENST00000453527 CTSB-006 11844320-11868087 protein_coding
  ENST00000505496 CTSB-033 11850889-11868040 protein_coding
  ENST00000524500 CTSB-016 11850897-11868070 protein_coding
  ENST00000524654 CTSB-025 11853358-11854925 protein_coding
  ENST00000525076 CTSB-026 11848487-11868058 processed_transcript
  ENST00000525315 CTSB-034 11850615-11853462 retained_intron
  ENST00000526195 CTSB-020 11849046-11868735 protein_coding
  ENST00000526481 CTSB-042 11842524-11845793 nonsense_mediated_decay
  ENST00000526645 CTSB-027 11849084-11868713 protein_coding
  ENST00000527215 CTSB-014 11852617-11868089 protein_coding
  ENST00000527243 CTSB-021 11849061-11862468 protein_coding
  ENST00000528965 CTSB-032 11852656-11867530 protein_coding
  ENST00000530290 CTSB-038 11847117-11848627 processed_transcript
  ENST00000530296 CTSB-019 11848104-11868917 protein_coding
  ENST00000530624 CTSB-039 11845661-11848509 processed_transcript
  ENST00000530640 CTSB-003 11844053-11868112 protein_coding
  ENST00000531089 CTSB-004 11844094-11868112 protein_coding
  ENST00000531502 CTSB-013 11850917-11868118 protein_coding
  ENST00000531551 CTSB-011 11844324-11868040 nonsense_mediated_decay
  ENST00000532370 CTSB-035 11850865-11853819 retained_intron
  ENST00000532392 CTSB-024 11853393-11868089 protein_coding
  ENST00000532409 CTSB-036 11847093-11849578 retained_intron
  ENST00000532656 CTSB-030 11852610-11868114 protein_coding
  ENST00000533110 CTSB-037 11847679-11850047 processed_transcript
  ENST00000533455 CTSB-002 11844355-11868106 protein_coding
  ENST00000533572 CTSB-017 11848089-11867693 protein_coding
  ENST00000534149 CTSB-018 11849062-11868739 protein_coding
  ENST00000534382 CTSB-023 11852610-11869448 protein_coding
  ENST00000534510 CTSB-005 11844370-11868106 protein_coding
  ENST00000534636 CTSB-015 11848074-11868052 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000353047ENST00000420692ENST00000453527ENST00000530640ENST00000531089ENST00000531551ENST00000533455ENST00000534510
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000353047 N/A 36.811±0.00 6.997±0.00 15.167±9.55 N/A N/A 28.548±0.00 14.593±0.00 45.676±0.00 5.932±0.00 41.758±0.00 32.531±18.37 56.980±7.45 25.892±0.00
ENST00000420692 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.128±0.00 N/A N/A N/A
ENST00000453527 172.643±0.00 104.785±0.00 N/A N/A 95.874±0.00 N/A 38.256±0.00 107.232±54.14 58.646±40.60 79.325±0.00 N/A 106.381±10.31 304.919±35.81 39.985±0.00
ENST00000530640 N/A N/A 28.485±0.00 24.029±0.00 75.833±0.00 33.523±0.00 18.390±0.00 90.745±0.00 38.335±0.00 58.114±0.00 N/A 50.209±12.48 108.436±0.00 5.447±0.00
ENST00000531089 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.814±0.00 N/A N/A N/A
ENST00000531551 N/A N/A 18.852±0.00 14.663±0.00 N/A N/A 7.696±0.00 N/A 11.524±0.00 21.421±0.00 N/A N/A N/A N/A
ENST00000533455 287.071±0.00 93.900±0.00 51.260±0.00 78.812±46.53 137.392±85.01 90.628±62.07 88.004±77.72 145.275±60.79 120.300±110.66 171.736±147.88 85.804±70.27 104.495±66.65 177.686±30.84 37.625±28.40
ENST00000534510 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.150±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008Y4 CIL_0008Y4_0001 VISTA 8:11271783-11873892
CIL_000919 CIL_000919_0001 VISTA 8:11446673-12047186
CIL_0007PQ CIL_0007PQ_0001 VISTA 8:11649159-12249913

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0004197 IEA:IDA cysteine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005518 IDA collagen binding
GO:0005576 TAS extracellular region
GO:0005615 ISS extracellular space
GO:0005622 TAS intracellular
GO:0005730 IDA nucleolus
GO:0005739 IEA mitochondrion
GO:0005764 IDA lysosome
GO:0006508 IEA:IDA proteolysis
GO:0008233 IDA peptidase activity
GO:0008234 IEA:IDA cysteine-type peptidase activity
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0030574 IDA collagen catabolic process
GO:0030855 IEP epithelial cell differentiation
GO:0036021 TAS endolysosome lumen
GO:0042981 TAS regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043394 IPI proteoglycan binding
GO:0045087 TAS innate immune response
GO:0046697 IEA decidualization
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050790 IEA regulation of catalytic activity
GO:0051603 IDA proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0097067 IEP cellular response to thyroid hormone stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055120 ctsba cathepsin B, a protein_coding Danio_rerio
ENSDARG00000067570 ctsbb capthepsin B, b protein_coding Danio_rerio
ENSMUSG00000021939 Ctsb cathepsin B protein_coding Mus_musculus

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