C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATP-binding cassette, sub-family A (ABC1), member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165029 ABCA1 9606 - 9:104781002-104928237 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374733 ABCA1-004 104861438-104928139 protein_coding
  ENST00000374736 ABCA1-002 104781002-104928237 protein_coding
  ENST00000423487 ABCA1-001 104855566-104928139 protein_coding
  ENST00000494467 ABCA1-003 104825591-104830989 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374736
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374736 14.146±0.00 1.765±0.00 0.881±0.05 2.628±0.00 4.255±2.43 1.276±0.39 9.981±0.00 5.033±3.02 11.218±0.00 2.036±0.83 2.014±0.85 3.634±1.58 0.594±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00022C CIL_00022C_0002 CGP 9:104781002-105439171

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002790 IEA peptide secretion
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005543 IC phospholipid binding
GO:0005548 IDA phospholipid transporter activity
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006200 IEA ATP catabolic process
GO:0006497 IEA protein lipidation
GO:0006911 IEA phagocytosis, engulfment
GO:0007040 IDA lysosome organization
GO:0007186 IMP G-protein coupled receptor signaling pathway
GO:0007584 IEA response to nutrient
GO:0008203 IDA cholesterol metabolic process
GO:0008509 ISS anion transmembrane transporter activity
GO:0009897 IEA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010745 TAS negative regulation of macrophage derived foam cell differentiation
GO:0010875 IEA positive regulation of cholesterol efflux
GO:0010887 TAS negative regulation of cholesterol storage
GO:0015485 IC cholesterol binding
GO:0015914 IEA phospholipid transport
GO:0016197 IDA endosomal transport
GO:0016887 IEA ATPase activity
GO:0017127 IDA cholesterol transporter activity
GO:0019905 IPI syntaxin binding
GO:0030139 IDA endocytic vesicle
GO:0030301 IEA cholesterol transport
GO:0030819 IMP positive regulation of cAMP biosynthetic process
GO:0031267 IPI small GTPase binding
GO:0032367 IMP intracellular cholesterol transport
GO:0032489 IMP regulation of Cdc42 protein signal transduction
GO:0033344 IDA cholesterol efflux
GO:0033700 IDA phospholipid efflux
GO:0034185 IPI apolipoprotein binding
GO:0034186 IPI apolipoprotein A-I binding
GO:0034188 IDA apolipoprotein A-I receptor activity
GO:0034364 IEA high-density lipoprotein particle
GO:0034380 IMP high-density lipoprotein particle assembly
GO:0034616 IEP response to laminar fluid shear stress
GO:0038027 IDA apolipoprotein A-I-mediated signaling pathway
GO:0042157 TAS lipoprotein metabolic process
GO:0042158 IEA lipoprotein biosynthetic process
GO:0042493 IEA response to drug
GO:0042632 IDA cholesterol homeostasis
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043691 IMP reverse cholesterol transport
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045121 IDA membrane raft
GO:0045332 IEA phospholipid translocation
GO:0045335 IDA phagocytic vesicle
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050702 IMP interleukin-1 beta secretion
GO:0051117 IPI ATPase binding
GO:0055091 IMP phospholipid homeostasis
GO:0055098 IEP response to low-density lipoprotein particle
GO:0060155 IMP platelet dense granule organization
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071300 IEA cellular response to retinoic acid
GO:0071397 IEA cellular response to cholesterol

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074635 abca1a ATP-binding cassette, sub-family A (ABC1), member 1A protein_coding Danio_rerio
ENSDARG00000079009 abca1b ATP-binding cassette, sub-family A (ABC1), member 1B protein_coding Danio_rerio
ENSMUSG00000015243 Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 protein_coding Mus_musculus

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