C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165996 PTPLA 9606 - 10:17589032-17617377 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000326961 PTPLA-002 17615477-17617367 protein_coding
  ENST00000361271 PTPLA-001 17589032-17617377 protein_coding
  ENST00000466335 PTPLA-003 17599074-17617235 protein_coding
  ENST00000471481 PTPLA-005 17594209-17603828 retained_intron
  ENST00000498812 PTPLA-004 17590275-17603744 nonsense_mediated_decay
  ENST00000618390 PTPLA-201 17615745-17617374 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361271ENST00000466335ENST00000471481ENST00000498812
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361271 N/A 0.872±0.00 0.429±0.20 0.235±0.10 0.683±0.11 2.851±1.11 0.595±0.00 0.346±0.22 0.470±0.23 1.071±0.01 0.354±0.29 0.123±0.00 0.405±0.31
ENST00000466335 2.488±0.00 3.945±0.00 1.203±0.22 1.163±0.12 5.376±0.00 13.213±9.39 3.257±0.00 1.924±1.20 2.213±0.26 3.062±0.00 1.998±1.05 1.525±0.50 2.288±0.73
ENST00000471481 1.141±0.00 N/A N/A N/A N/A N/A 1.316±0.00 N/A N/A 2.732±1.35 N/A 0.276±0.00 N/A
ENST00000498812 1.222±0.00 2.522±0.00 0.582±0.00 1.169±0.00 3.304±0.00 22.806±0.00 0.935±0.00 0.466±0.00 3.044±0.00 3.248±1.48 1.438±0.33 1.077±0.47 2.464±0.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005AP CIL_0005AP_0001 CGP 10:17318383-17617377
CIL_0006BI CIL_0006BI_0001 CGP 10:17589032-17715914

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004725 TAS protein tyrosine phosphatase activity
GO:0005783 IEA endoplasmic reticulum
GO:0006470 TAS protein dephosphorylation
GO:0006633 IEA fatty acid biosynthetic process
GO:0007165 NAS signal transduction
GO:0007275 IEA multicellular organismal development
GO:0010389 IEA regulation of G2/M transition of mitotic cell cycle
GO:0014902 IEA myotube differentiation
GO:0016021 IEA integral component of membrane
GO:0016829 IEA lyase activity
GO:0035335 TAS peptidyl-tyrosine dephosphorylation
GO:2000045 IEA regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022633 PTPLA protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A protein_coding Danio_rerio
ENSMUSG00000063275 Ptpla protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a protein_coding Mus_musculus

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