C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167258 CDK12 9606 + 17:39461511-39564907 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000430627 CDK12-008 39461761-39532477 protein_coding
  ENST00000447079 CDK12-001 39462039-39535146 protein_coding
  ENST00000558240 CDK12-003 39550191-39564830 processed_transcript
  ENST00000559545 CDK12-004 39547821-39564907 processed_transcript
  ENST00000559663 CDK12-002 39525867-39551141 nonsense_mediated_decay
  ENST00000581593 CDK12-011 39471514-39494692 processed_transcript
  ENST00000581963 CDK12-005 39543991-39546682 retained_intron
  ENST00000584336 CDK12-007 39529882-39531844 retained_intron
  ENST00000584632 CDK12-010 39461511-39526163 protein_coding
  ENST00000585161 CDK12-006 39548941-39550976 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000430627ENST00000447079ENST00000584632
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000430627 2.804±0.00 1.334±0.00 N/A 1.649±0.00 1.928±0.00 1.923±0.98 1.685±0.00 2.069±0.00 1.145±0.05 1.478±0.27 1.595±0.00 3.500±2.34 2.924±1.07 6.613±3.68
ENST00000447079 1.096±0.00 1.019±0.00 0.914±0.00 0.812±0.32 0.984±0.23 1.857±0.00 0.834±0.46 1.816±0.40 1.306±0.15 2.254±0.08 0.191±0.00 2.540±0.87 1.402±0.46 3.587±0.00
ENST00000584632 N/A N/A 2.052±0.00 1.426±0.00 4.679±0.00 3.185±0.00 N/A 3.455±0.00 2.605±0.00 2.515±0.00 N/A 3.821±1.56 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SN CIL_0008SN_0001 VISTA 17:39110111-39710718
CIL_00080Z CIL_00080Z_0001 VISTA 17:39318232-39918735
CIL_00098W CIL_00098W_0001 VISTA 17:39359510-39962707
CIL_0007WH CIL_0007WH_0001 VISTA 17:39374871-39978277
CIL_0007D3 CIL_0007D3_0001 CGP 17:39404285-39564907
CIL_0007D4 CIL_0007D4_0001 CGP 17:39461511-39609777

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002944 IPI cyclin K-CDK12 complex
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004693 IEA cyclin-dependent protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0006397 IEA mRNA processing
GO:0006468 IEA protein phosphorylation
GO:0008353 IMP RNA polymerase II carboxy-terminal domain kinase activity
GO:0008380 ISS RNA splicing
GO:0016607 IDA nuclear speck
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019908 ISS nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0030332 IPI cyclin binding
GO:0043405 IMP regulation of MAP kinase activity
GO:0046777 IDA protein autophosphorylation
GO:0051726 IEA regulation of cell cycle
GO:0070816 IMP phosphorylation of RNA polymerase II C-terminal domain

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000003119 Cdk12 cyclin-dependent kinase 12 protein_coding Mus_musculus

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