C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: low density lipoprotein receptor class A domain containing 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168675 LDLRAD4 9606 + 18:13217498-13652755 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359446 LDLRAD4-002 13278103-13652754 protein_coding
  ENST00000361303 LDLRAD4-006 13620868-13652754 retained_intron
  ENST00000399848 LDLRAD4-001 13218787-13652755 protein_coding
  ENST00000435606 LDLRAD4-007 13620868-13652754 retained_intron
  ENST00000585931 LDLRAD4-004 13611764-13646734 protein_coding
  ENST00000586207 LDLRAD4-015 13542292-13645205 processed_transcript
  ENST00000586222 LDLRAD4-012 13382554-13438332 protein_coding
  ENST00000586765 LDLRAD4-018 13612619-13645659 protein_coding
  ENST00000587440 LDLRAD4-016 13542407-13543214 processed_transcript
  ENST00000587600 LDLRAD4-014 13465025-13491588 processed_transcript
  ENST00000587757 LDLRAD4-003 13611464-13645777 protein_coding
  ENST00000587905 LDLRAD4-010 13218026-13621143 protein_coding
  ENST00000590115 LDLRAD4-011 13218760-13278376 retained_intron
  ENST00000590308 LDLRAD4-005 13612029-13615748 processed_transcript
  ENST00000590371 LDLRAD4-009 13217498-13387577 processed_transcript
  ENST00000592657 LDLRAD4-017 13542916-13543623 processed_transcript
  ENST00000592812 LDLRAD4-019 13612625-13616159 processed_transcript
  ENST00000592991 LDLRAD4-008 13641758-13645712 protein_coding
  ENST00000593236 LDLRAD4-013 13465015-13621270 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359446ENST00000361303ENST00000399848ENST00000585931ENST00000586222ENST00000590308
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359446 0.917±0.00 1.282±0.00 0.878±0.00 3.524±0.00 2.006±0.43 0.913±0.00 2.243±0.00 0.687±0.00 0.783±0.00 N/A 0.955±0.63 0.979±0.00 0.904±0.37 2.753±0.00
ENST00000361303 N/A N/A N/A N/A 0.858±0.00 0.852±0.00 N/A N/A N/A N/A N/A N/A 0.413±0.00 N/A
ENST00000399848 0.610±0.00 N/A N/A N/A 0.700±0.00 0.308±0.00 0.922±0.53 0.450±0.00 N/A 0.728±0.00 N/A N/A 0.471±0.00 0.578±0.00
ENST00000585931 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.718±0.00 N/A N/A 2.037±0.00 N/A
ENST00000586222 N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.393±0.00 N/A 3.139±0.00 N/A N/A
ENST00000590308 N/A N/A N/A 5.858±3.12 N/A N/A N/A N/A N/A N/A N/A 0.448±0.00 N/A 0.767±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000LB CIL_0000LB_0001 CGP 18:12991362-13652755
CIL_0007Z8 CIL_0007Z8_0001 VISTA 18:13081739-13682600
CIL_0005Q2 CIL_0005Q2_0002 CGP 18:13217498-13726663

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005768 IEA endosome
GO:0010719 IMP negative regulation of epithelial to mesenchymal transition
GO:0010991 IDA negative regulation of SMAD protein complex assembly
GO:0016021 NAS integral component of membrane
GO:0030336 IMP negative regulation of cell migration
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031901 IDA early endosome membrane
GO:0060394 IDA negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0070412 IPI R-SMAD binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054941 ldlrad4 low density lipoprotein receptor class A domain containing 4 protein_coding Danio_rerio
ENSDARG00000070555 LDLRAD4 (2 of 2) low density lipoprotein receptor class A domain containing 4 protein_coding Danio_rerio
ENSMUSG00000024544 Ldlrad4 low density lipoprotein receptor class A domain containing 4 protein_coding Mus_musculus

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