C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cholinergic receptor, nicotinic, alpha 5 (neuronal)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169684 CHRNA5 9606 + 15:78565520-78595269 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000299565 CHRNA5-001 78565520-78595269 protein_coding
  ENST00000394802 CHRNA5-002 78580890-78593274 protein_coding
  ENST00000559554 CHRNA5-003 78565571-78593535 protein_coding
  ENST00000559576 CHRNA5-004 78590362-78593701 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000299565ENST00000394802ENST00000559554ENST00000559576
Transcript ID Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000299565 0.050±0.00 0.104±0.00 0.027±0.00 0.109±0.00 0.069±0.05 N/A N/A 0.028±0.00 0.052±0.00 N/A
ENST00000394802 N/A N/A N/A N/A N/A N/A N/A 0.191±0.00 N/A N/A
ENST00000559554 0.444±0.00 N/A 0.206±0.14 N/A 0.441±0.00 N/A 0.201±0.00 0.763±0.71 0.737±0.75 2.596±1.53
ENST00000559576 N/A 2.135±0.00 N/A N/A N/A 0.229±0.00 0.261±0.00 0.442±0.18 0.299±0.08 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003TW CIL_0003TW_0001 CGP 15:78540405-78595269
CIL_0003TT CIL_0003TT_0001 CGP 15:78565520-78621295

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004889 NAS acetylcholine-activated cation-selective channel activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005886 TAS plasma membrane
GO:0005892 IC acetylcholine-gated channel complex
GO:0006810 NAS:IEA transport
GO:0006811 IEA ion transport
GO:0006812 NAS cation transport
GO:0007165 NAS signal transduction
GO:0007268 TAS synaptic transmission
GO:0015276 TAS ligand-gated ion channel activity
GO:0015464 IDA acetylcholine receptor activity
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030054 IEA cell junction
GO:0034220 TAS ion transmembrane transport
GO:0035094 IEA response to nicotine
GO:0035095 IMP behavioral response to nicotine
GO:0045211 IEA postsynaptic membrane
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003420 chrna5 cholinergic receptor, nicotinic, alpha 5 protein_coding Danio_rerio
ENSMUSG00000035594 Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 protein_coding Mus_musculus

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