C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cholinergic receptor, nicotinic, beta 1 (muscle)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000170175 CHRNB1 9606 + 17:7445061-7457707 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306071 CHRNB1-001 7445061-7457707 protein_coding
  ENST00000536404 CHRNB1-002 7445503-7456926 protein_coding
  ENST00000570557 CHRNB1-007 7445339-7455860 protein_coding
  ENST00000572857 CHRNB1-004 7445064-7447089 protein_coding
  ENST00000573209 CHRNB1-003 7445543-7455689 retained_intron
  ENST00000574054 CHRNB1-005 7445108-7445774 retained_intron
  ENST00000575379 CHRNB1-008 7455594-7457329 protein_coding
  ENST00000576360 CHRNB1-006 7445531-7457315 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306071ENST00000536404ENST00000570557ENST00000572857ENST00000573209ENST00000575379ENST00000576360
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306071 0.377±0.00 N/A N/A 1.300±0.00 1.091±0.59 N/A 1.350±0.00 1.444±1.14 1.315±0.00 0.479±0.36 17.142±5.02 1.907±0.00 6.393±3.16 3.258±0.00
ENST00000536404 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 25.826±0.00 N/A N/A N/A
ENST00000570557 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.533±4.43 15.146±0.00 N/A
ENST00000572857 N/A N/A N/A N/A N/A 0.494±0.00 N/A N/A N/A N/A N/A 2.206±0.00 N/A N/A
ENST00000573209 N/A N/A N/A N/A N/A N/A N/A 0.474±0.00 N/A N/A N/A N/A N/A N/A
ENST00000575379 1.843±0.00 4.727±0.00 0.419±0.00 2.094±0.75 2.874±2.15 2.134±0.00 2.224±0.00 2.864±1.44 0.752±0.19 2.253±0.00 N/A 6.349±1.45 7.379±1.10 N/A
ENST00000576360 N/A N/A N/A N/A N/A 0.326±0.00 N/A 0.578±0.00 N/A N/A N/A 14.948±0.00 9.970±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006ST CIL_0006ST_0002 CGP 17:7438273-7457707

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001941 IMP postsynaptic membrane organization
GO:0003009 IEA skeletal muscle contraction
GO:0004889 ISS acetylcholine-activated cation-selective channel activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0005892 IMP acetylcholine-gated channel complex
GO:0006810 IEA transport
GO:0006811 IEA ion transport
GO:0006812 IMP cation transport
GO:0006936 IMP muscle contraction
GO:0007165 IMP signal transduction
GO:0007271 IMP synaptic transmission, cholinergic
GO:0007274 IMP neuromuscular synaptic transmission
GO:0015267 IMP channel activity
GO:0015276 ISS ligand-gated ion channel activity
GO:0015464 IMP acetylcholine receptor activity
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030054 IEA cell junction
GO:0034220 ISS ion transmembrane transport
GO:0035095 IMP behavioral response to nicotine
GO:0042166 ISS acetylcholine binding
GO:0042391 ISS regulation of membrane potential
GO:0045202 IMP synapse
GO:0045211 IEA postsynaptic membrane
GO:0048747 IMP muscle fiber development
GO:0050877 IMP neurological system process
GO:0055085 IMP transmembrane transport
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022532 chrnb1l cholinergic receptor, nicotinic, beta 1 (muscle) like protein_coding Danio_rerio
ENSDARG00000069660 chrnb1 cholinergic receptor, nicotinic, beta 1 (muscle) protein_coding Danio_rerio
ENSMUSG00000041189 Chrnb1 cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) protein_coding Mus_musculus

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