C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cadherin 2, type 1, N-cadherin (neuronal)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000170558 CDH2 9606 - 18:27950966-28177446 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000269141 CDH2-001 27950966-28177446 protein_coding
  ENST00000399380 CDH2-003 27951081-28036585 protein_coding
  ENST00000413878 CDH2-004 28011918-28159297 protein_coding
  ENST00000418492 CDH2-002 28005970-28045596 protein_coding
  ENST00000430882 CDH2-005 28009804-28097229 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000269141ENST00000399380ENST00000413878
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000269141 0.103±0.00 N/A 1.598±0.00 8.187±1.15 0.042±0.00 2.370±0.00 49.755±35.79 5.074±0.13 3.440±2.97 0.372±0.00 N/A 2.600±0.59 0.169±0.00 7.074±4.27
ENST00000399380 0.030±0.00 0.479±0.00 1.341±0.00 3.714±0.00 0.602±0.00 0.403±0.00 5.031±0.00 5.647±0.00 N/A 0.076±0.00 0.056±0.00 1.320±1.20 0.261±0.19 6.998±3.83
ENST00000413878 N/A N/A N/A N/A 1.379±0.00 1.129±0.00 N/A N/A 1.507±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008EG CIL_0008EG_0001 VISTA 18:27620941-28224250
CIL_0008EE CIL_0008EE_0001 VISTA 18:27783899-28388892
CIL_0006EO CIL_0006EO_0001 CGP 18:27950966-31042815

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005912 IEA adherens junction
GO:0005913 IDA cell-cell adherens junction
GO:0005916 IEA fascia adherens
GO:0005925 IDA focal adhesion
GO:0007155 TAS cell adhesion
GO:0007156 IEA homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 IEA heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0008013 TAS beta-catenin binding
GO:0010001 ISS glial cell differentiation
GO:0014704 ISS intercalated disc
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016324 IEA apical plasma membrane
GO:0016339 IEA calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0016342 IDA catenin complex
GO:0016477 IEA cell migration
GO:0019899 IEA enzyme binding
GO:0019903 IEA protein phosphatase binding
GO:0030027 IEA lamellipodium
GO:0034329 TAS cell junction assembly
GO:0034332 TAS adherens junction organization
GO:0042692 TAS muscle cell differentiation
GO:0043410 IEA positive regulation of MAPK cascade
GO:0044331 ISS cell-cell adhesion mediated by cadherin
GO:0045202 IEA synapse
GO:0045216 TAS cell-cell junction organization
GO:0045294 IPI alpha-catenin binding
GO:0045295 IPI gamma-catenin binding
GO:0048514 IEA blood vessel morphogenesis
GO:0051146 IEA striated muscle cell differentiation
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0070062 IDA extracellular vesicular exosome
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0097150 ISS neuronal stem cell maintenance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018693 cdh2 cadherin 2, neuronal protein_coding Danio_rerio
ENSMUSG00000024304 Cdh2 cadherin 2 protein_coding Mus_musculus

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