C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mutated in colorectal cancers
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171444 MCC 9606 - 5:113022099-113488830 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302475 MCC-001 113022099-113294949 protein_coding
  ENST00000408903 MCC-003 113027302-113488830 protein_coding
  ENST00000502648 MCC-004 113101500-113122830 retained_intron
  ENST00000505604 MCC-008 113101543-113104625 retained_intron
  ENST00000506605 MCC-007 113101734-113203317 processed_transcript
  ENST00000511242 MCC-010 113448123-113488823 processed_transcript
  ENST00000511847 MCC-006 113101734-113204576 processed_transcript
  ENST00000514701 MCC-009 113048876-113294938 protein_coding
  ENST00000515367 MCC-011 113026132-113234677 protein_coding
  ENST00000624689 MCC-012 113048563-113064040 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302475ENST00000408903ENST00000506605ENST00000511847ENST00000515367ENST00000624689
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302475 3.222±0.00 0.486±0.00 0.486±0.00 1.232±0.30 1.157±0.23 1.305±0.00 2.721±0.30 1.559±0.00 2.540±1.55 1.060±0.35 0.386±0.27 5.200±4.66 1.886±1.33 1.103±0.00
ENST00000408903 N/A N/A N/A N/A N/A N/A N/A N/A 2.660±0.00 N/A N/A N/A N/A N/A
ENST00000506605 N/A N/A N/A N/A N/A N/A 7.421±0.00 N/A 8.422±0.00 N/A N/A N/A N/A N/A
ENST00000511847 N/A N/A N/A 2.440±0.00 N/A N/A N/A 7.591±0.00 N/A 4.310±0.00 N/A 11.933±0.00 N/A N/A
ENST00000515367 N/A N/A 0.649±0.00 0.429±0.00 N/A N/A N/A 1.293±0.00 2.152±0.00 N/A 1.061±0.00 3.129±0.00 N/A N/A
ENST00000624689 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.505±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004UM CIL_0004UM_0001 CGP 5:112976702-113488830

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0004872 TAS receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0007165 TAS signal transduction
GO:0010633 IMP negative regulation of epithelial cell migration
GO:0016055 IEA Wnt signaling pathway
GO:0042995 IEA cell projection
GO:0050680 IDA negative regulation of epithelial cell proliferation
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087450 MCC mutated in colorectal cancers protein_coding Danio_rerio
ENSMUSG00000071856 Mcc mutated in colorectal cancers protein_coding Mus_musculus

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