C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: additional sex combs like transcriptional regulator 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171456 ASXL1 9606 + 20:32358344-32439319 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306058 ASXL1-201 32359747-32439318 protein_coding
  ENST00000375687 ASXL1-001 32358352-32439319 protein_coding
  ENST00000375689 ASXL1-002 32359565-32372553 protein_coding
  ENST00000470145 ASXL1-004 32366384-32429920 retained_intron
  ENST00000497249 ASXL1-003 32358811-32372242 protein_coding
  ENST00000542461 ASXL1-202 32358344-32372547 protein_coding
  ENST00000553345 ASXL1-006 32430862-32433410 processed_transcript
  ENST00000555343 ASXL1-005 32360017-32372238 protein_coding
  ENST00000555564 ASXL1-007 32431017-32432972 retained_intron
  ENST00000613218 ASXL1-203 32358344-32439318 protein_coding
  ENST00000619344 ASXL1-008 32429740-32431627 processed_transcript
  ENST00000620121 ASXL1-204 32358413-32437891 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306058ENST00000375687ENST00000497249ENST00000553345ENST00000613218ENST00000620121
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306058 1.945±0.00 N/A 1.779±0.00 0.716±0.00 2.181±0.00 0.772±0.00 1.371±0.00 1.173±0.00 1.533±0.00 N/A 1.793±0.00 2.392±0.69 3.784±0.58 3.360±0.00
ENST00000375687 6.239±0.00 N/A N/A 2.847±0.00 2.362±0.00 6.230±0.00 1.293±1.01 5.202±0.00 1.884±0.00 N/A 3.318±0.00 8.557±2.96 4.363±1.51 7.082±1.13
ENST00000497249 N/A N/A N/A N/A N/A N/A N/A 27.787±0.00 N/A N/A N/A N/A N/A N/A
ENST00000553345 N/A N/A N/A N/A N/A N/A 1.053±0.00 N/A N/A N/A N/A 13.944±0.00 9.072±0.00 32.771±0.00
ENST00000613218 N/A N/A N/A N/A 1.218±0.00 N/A N/A N/A N/A N/A 1.127±0.00 N/A N/A N/A
ENST00000620121 4.306±0.00 6.335±0.00 N/A 1.793±0.00 3.006±0.00 0.458±0.00 2.151±0.00 0.717±0.00 1.123±0.00 4.665±3.28 1.842±0.00 2.139±0.00 N/A 9.034±0.43

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008A4 CIL_0008A4_0001 VISTA 20:32224531-32829311
CIL_0001KF CIL_0001KF_0001 CGP 20:32277664-32439319
CIL_0008NQ CIL_0008NQ_0001 VISTA 20:32326689-32928341
CIL_0001KE CIL_0001KE_0001 CGP 20:32358344-32585074

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 ISS nuclear chromatin
GO:0003677 IEA DNA binding
GO:0003713 ISS transcription coactivator activity
GO:0003714 ISS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0032526 ISS response to retinoic acid
GO:0035359 ISS negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035517 IDA PR-DUB complex
GO:0035522 IDA monoubiquitinated histone H2A deubiquitination
GO:0042974 ISS retinoic acid receptor binding
GO:0042975 ISS peroxisome proliferator activated receptor binding
GO:0045599 ISS negative regulation of fat cell differentiation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048386 ISS positive regulation of retinoic acid receptor signaling pathway
GO:0048387 ISS negative regulation of retinoic acid receptor signaling pathway
GO:0060348 IEA bone development
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036956 asxl1 additional sex combs like 1 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000042548 Asxl1 additional sex combs like 1 protein_coding Mus_musculus

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