C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myeloid differentiation primary response 88
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000172936 MYD88 9606 + 3:38138478-38143022 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000396334 MYD88-001 38138478-38143022 protein_coding
  ENST00000416282 MYD88-002 38138651-38143022 retained_intron
  ENST00000417037 MYD88-201 38138478-38143019 protein_coding
  ENST00000421516 MYD88-006 38138665-38143022 protein_coding
  ENST00000424893 MYD88-011 38138552-38141660 protein_coding
  ENST00000443433 MYD88-009 38138661-38141450 protein_coding
  ENST00000460295 MYD88-003 38138657-38140579 retained_intron
  ENST00000463956 MYD88-012 38139740-38141265 processed_transcript
  ENST00000481122 MYD88-013 38139152-38141314 processed_transcript
  ENST00000484513 MYD88-007 38139423-38143019 retained_intron
  ENST00000495303 MYD88-008 38138657-38141643 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000396334ENST00000416282ENST00000421516ENST00000495303
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000396334 3.370±0.00 N/A N/A N/A 3.707±0.76 0.923±0.00 1.666±0.00 3.145±0.00 8.917±0.00 7.807±0.00 N/A 10.103±4.78 12.980±6.53 2.033±0.00
ENST00000416282 N/A 3.030±0.00 0.194±0.00 0.805±0.00 N/A N/A N/A 2.285±0.00 N/A N/A N/A 3.023±0.00 N/A N/A
ENST00000421516 N/A 13.420±0.00 0.150±0.00 2.485±0.00 N/A 2.338±0.00 2.546±0.00 5.202±0.00 5.625±0.00 5.220±4.80 0.555±0.00 3.679±3.43 8.813±6.14 2.297±0.59
ENST00000495303 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.627±0.00 10.437±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002238 IEA response to molecule of fungal origin
GO:0002755 TAS:IEA MyD88-dependent toll-like receptor signaling pathway
GO:0005102 IEA receptor binding
GO:0005121 IEA Toll binding
GO:0005123 TAS death receptor binding
GO:0005149 IEA interleukin-1 receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006954 IEA inflammatory response
GO:0007165 NAS:IEA signal transduction
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007254 IEA JNK cascade
GO:0008063 IEA Toll signaling pathway
GO:0009615 IEA response to virus
GO:0010008 TAS endosome membrane
GO:0014069 IEA postsynaptic density
GO:0016064 IEA immunoglobulin mediated immune response
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0032481 TAS positive regulation of type I interferon production
GO:0032494 IEA response to peptidoglycan
GO:0032496 IEA response to lipopolysaccharide
GO:0032740 ISS positive regulation of interleukin-17 production
GO:0032747 ISS positive regulation of interleukin-23 production
GO:0032755 ISS positive regulation of interleukin-6 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042127 IEA regulation of cell proliferation
GO:0042802 IPI identical protein binding
GO:0043066 TAS negative regulation of apoptotic process
GO:0043123 IEP:IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0044130 IEA negative regulation of growth of symbiont in host
GO:0045080 IEA positive regulation of chemokine biosynthetic process
GO:0045087 TAS innate immune response
GO:0045351 IEA type I interferon biosynthetic process
GO:0046330 IEA positive regulation of JNK cascade
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050671 IEA positive regulation of lymphocyte proliferation
GO:0050727 ISS regulation of inflammatory response
GO:0050830 ISS defense response to Gram-positive bacterium
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0070555 IMP response to interleukin-1
GO:0070935 IDA 3'-UTR-mediated mRNA stabilization
GO:0070976 IPI:IEA TIR domain binding
GO:0071260 IEP cellular response to mechanical stimulus
GO:0090557 IEA establishment of endothelial intestinal barrier

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010169 myd88 myeloid differentiation primary response gene (88) protein_coding Danio_rerio
ENSMUSG00000032508 Myd88 myeloid differentiation primary response gene 88 protein_coding Mus_musculus

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