C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000175166 PSMD2 9606 + 3:184298709-184309054 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000310118 PSMD2-001 184298709-184309054 protein_coding
  ENST00000417952 PSMD2-004 184299198-184302692 protein_coding
  ENST00000432855 PSMD2-017 184305847-184307902 protein_coding
  ENST00000433010 PSMD2-008 184299254-184302064 nonsense_mediated_decay
  ENST00000435761 PSMD2-002 184300581-184309000 protein_coding
  ENST00000439383 PSMD2-003 184300581-184309048 protein_coding
  ENST00000445558 PSMD2-010 184299904-184302775 nonsense_mediated_decay
  ENST00000459910 PSMD2-005 184299235-184301935 processed_transcript
  ENST00000460628 PSMD2-014 184302740-184303915 retained_intron
  ENST00000463602 PSMD2-011 184300586-184302422 processed_transcript
  ENST00000466987 PSMD2-015 184303028-184304011 retained_intron
  ENST00000473991 PSMD2-019 184306611-184308534 processed_transcript
  ENST00000476461 PSMD2-009 184299257-184300444 retained_intron
  ENST00000485937 PSMD2-012 184301722-184302772 retained_intron
  ENST00000487475 PSMD2-006 184299239-184302061 retained_intron
  ENST00000488085 PSMD2-016 184304062-184306103 retained_intron
  ENST00000491149 PSMD2-013 184302030-184303685 retained_intron
  ENST00000491494 PSMD2-020 184307922-184308724 retained_intron
  ENST00000492191 PSMD2-007 184299251-184300652 retained_intron
  ENST00000496925 PSMD2-018 184305861-184307677 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000310118ENST00000417952ENST00000432855ENST00000433010ENST00000439383ENST00000445558ENST00000496925
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000310118 N/A N/A 1.250±0.00 11.795±3.82 3.712±0.00 7.186±0.95 5.618±0.00 9.761±6.76 8.290±0.00 4.181±0.00 6.879±0.00 28.806±18.48 N/A N/A
ENST00000417952 37.580±0.00 N/A N/A 38.164±0.00 N/A N/A 47.920±0.00 N/A N/A N/A 152.780±0.00 151.887±0.00 104.167±0.00 86.830±13.99
ENST00000432855 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 61.605±0.00
ENST00000433010 N/A N/A 4.982±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000439383 37.206±0.00 40.182±0.00 5.126±0.00 12.272±6.42 28.147±20.17 19.392±13.52 21.181±18.53 18.951±15.08 21.215±0.00 14.362±10.83 76.361±63.66 69.991±49.40 61.953±16.41 80.780±13.75
ENST00000445558 N/A N/A 7.784±0.00 N/A N/A N/A N/A N/A 9.745±0.00 N/A N/A N/A N/A N/A
ENST00000496925 N/A N/A N/A N/A N/A N/A N/A 4.157±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005G3 CIL_0005G3_0001 CGP 3:184135038-184684758
CIL_000571 CIL_000571_0001 CGP 3:184259213-184309054
CIL_000572 CIL_000572_0001 CGP 3:184298709-184335358

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA:IEA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0005838 TAS proteasome regulatory particle
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0022624 ISS proteasome accessory complex
GO:0030234 IEA enzyme regulator activity
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042176 IEA regulation of protein catabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087758 PSMD2 (1 of 2) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 protein_coding Danio_rerio
ENSDARG00000088574 psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 protein_coding Danio_rerio
ENSMUSG00000006998 Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 protein_coding Mus_musculus
ENSMUSG00000039684 Gm5422 predicted pseudogene 5422 protein_coding Mus_musculus

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