C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein tyrosine phosphatase, non-receptor type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000175354 PTPN2 9606 - 18:12785478-12929643 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309660 PTPN2-002 12792153-12884235 protein_coding
  ENST00000327283 PTPN2-003 12785478-12884338 protein_coding
  ENST00000353319 PTPN2-001 12785483-12884281 protein_coding
  ENST00000585666 PTPN2-014 12785506-12814305 protein_coding
  ENST00000587497 PTPN2-013 12814197-12819000 processed_transcript
  ENST00000587703 PTPN2-012 12785685-12836824 protein_coding
  ENST00000589086 PTPN2-009 12836824-12862473 processed_transcript
  ENST00000589216 PTPN2-008 12817181-12884198 nonsense_mediated_decay
  ENST00000589444 PTPN2-006 12785478-12787741 retained_intron
  ENST00000591115 PTPN2-004 12785481-12884214 protein_coding
  ENST00000591305 PTPN2-007 12801989-12884222 nonsense_mediated_decay
  ENST00000591497 PTPN2-005 12792302-12843981 protein_coding
  ENST00000591901 PTPN2-015 12785481-12802153 protein_coding
  ENST00000592059 PTPN2-011 12825804-12929643 protein_coding
  ENST00000592776 PTPN2-010 12814325-12884277 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309660ENST00000327283ENST00000587497ENST00000587703ENST00000589444ENST00000591115ENST00000591305ENST00000591497ENST00000591901ENST00000592776
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309660 0.807±0.00 N/A 0.405±0.00 1.041±0.37 1.370±0.61 0.433±0.00 0.483±0.12 1.140±0.00 0.477±0.00 1.215±0.15 N/A 1.097±0.05 0.452±0.05 1.217±0.00
ENST00000327283 3.697±0.00 N/A N/A 0.931±0.00 3.218±1.13 2.854±0.44 1.399±0.55 1.778±0.00 3.411±0.00 4.360±0.94 2.169±0.00 5.138±1.13 5.093±0.06 4.165±0.00
ENST00000587497 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.814±0.00 N/A N/A N/A
ENST00000587703 7.897±0.00 N/A N/A N/A 4.865±0.00 6.481±0.00 0.724±0.00 10.183±0.00 3.227±0.00 7.881±0.00 2.092±1.37 8.579±0.00 N/A 8.527±0.00
ENST00000589444 N/A 3.683±0.00 0.639±0.00 0.741±0.00 1.202±0.34 1.768±0.00 0.327±0.00 1.675±0.01 0.551±0.00 1.609±0.58 N/A 1.796±0.34 N/A N/A
ENST00000591115 N/A N/A 1.097±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000591305 N/A N/A N/A 1.473±0.00 N/A N/A N/A N/A N/A N/A 2.065±0.00 N/A N/A N/A
ENST00000591497 N/A 2.276±0.00 N/A N/A N/A 0.885±0.00 N/A N/A 0.996±0.00 N/A N/A N/A N/A N/A
ENST00000591901 N/A 11.338±0.00 N/A N/A 2.621±0.00 2.420±0.00 N/A N/A N/A N/A 2.645±0.00 N/A N/A N/A
ENST00000592776 N/A N/A N/A 1.943±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005Q0 CIL_0005Q0_0002 CGP 18:12661833-12929643
CIL_00068W CIL_00068W_0001 CGP 18:12785478-12987536

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004725 IMP:IEA protein tyrosine phosphatase activity
GO:0005178 IPI integrin binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005793 IDA endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 IDA plasma membrane
GO:0006470 IEA protein dephosphorylation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008286 ISS insulin receptor signaling pathway
GO:0010804 ISS negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 ISS negative regulation of lipid storage
GO:0016311 IEA dephosphorylation
GO:0016791 IEA phosphatase activity
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019901 IPI protein kinase binding
GO:0019905 IPI syntaxin binding
GO:0030183 ISS B cell differentiation
GO:0030217 ISS T cell differentiation
GO:0030218 ISS erythrocyte differentiation
GO:0030971 IPI receptor tyrosine kinase binding
GO:0035335 IMP peptidyl-tyrosine dephosphorylation
GO:0042059 IMP negative regulation of epidermal growth factor receptor signaling pathway
GO:0042512 IMP negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518 IDA negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524 ISS negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527 IMP negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042593 ISS glucose homeostasis
GO:0045650 ISS negative regulation of macrophage differentiation
GO:0045722 ISS positive regulation of gluconeogenesis
GO:0046627 ISS negative regulation of insulin receptor signaling pathway
GO:0050728 ISS negative regulation of inflammatory response
GO:0050860 ISS negative regulation of T cell receptor signaling pathway
GO:0050922 ISS negative regulation of chemotaxis
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060334 TAS regulation of interferon-gamma-mediated signaling pathway
GO:0060336 ISS negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 IMP negative regulation of type I interferon-mediated signaling pathway
GO:0070104 IMP negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:1902202 IMP regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 IMP negative regulation of interleukin-2-mediated signaling pathway
GO:1902212 ISS negative regulation of prolactin signaling pathway
GO:1902215 IMP negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 ISS negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 ISS negative regulation of positive thymic T cell selection
GO:2000587 ISS negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016481 ptpn2a protein tyrosine phosphatase, non-receptor type 2, a protein_coding Danio_rerio
ENSDARG00000035986 ptpn2b protein tyrosine phosphatase, non-receptor type 2, b protein_coding Danio_rerio
ENSMUSG00000024539 Ptpn2 protein tyrosine phosphatase, non-receptor type 2 protein_coding Mus_musculus

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