C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein tyrosine phosphatase, non-receptor type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024539 Ptpn2 10090 - 18:67665511-67724595 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025420 Ptpn2-001 67665512-67724588 protein_coding
  ENSMUST00000120934 Ptpn2-003 67665511-67724573 protein_coding
  ENSMUST00000122412 Ptpn2-002 67671212-67724595 protein_coding
  ENSMUST00000128169 Ptpn2-004 67675818-67690224 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025420ENSMUST00000120934ENSMUST00000122412ENSMUST00000128169
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025420 1.624±0.62 1.395±0.55 4.864±0.72 3.689±0.68 1.542±0.21 2.421±0.68 1.288±0.17 1.316±0.52 5.436±4.07 1.910±0.00 2.887±0.59 2.694±2.49 15.753±4.02 2.380±0.40
ENSMUST00000120934 0.668±0.09 1.214±0.00 N/A 1.147±0.00 1.517±0.41 2.412±0.00 N/A 0.982±0.49 1.201±0.31 2.111±0.51 0.497±0.00 2.836±2.62 N/A 1.840±1.00
ENSMUST00000122412 0.750±0.27 0.747±0.26 0.875±0.07 1.845±1.23 0.804±0.23 0.843±0.56 0.466±0.10 0.529±0.07 1.032±0.34 0.936±0.32 0.638±0.15 1.156±0.44 2.276±0.11 1.089±0.11
ENSMUST00000128169 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.614±0.06 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ZP CIL_0007ZP_0002 VISTA 18:67068230-67671525
CIL_0001BA CIL_0001BA_0002 CGP 18:67641599-67724595
CIL_00068W CIL_00068W_0002 CGP 18:67665511-67795461

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004725 IMP protein tyrosine phosphatase activity
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005783 ISS endoplasmic reticulum
GO:0005793 ISS endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 ISS plasma membrane
GO:0006470 IMP protein dephosphorylation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008286 IMP insulin receptor signaling pathway
GO:0010804 IMP negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 IMP negative regulation of lipid storage
GO:0019901 IEA protein kinase binding
GO:0019905 IEA syntaxin binding
GO:0030183 IMP B cell differentiation
GO:0030217 IMP T cell differentiation
GO:0030218 IMP erythrocyte differentiation
GO:0030971 IEA receptor tyrosine kinase binding
GO:0035335 IMP peptidyl-tyrosine dephosphorylation
GO:0042059 ISS negative regulation of epidermal growth factor receptor signaling pathway
GO:0042512 ISS negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518 ISS negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524 IMP negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527 IMP negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042593 IMP glucose homeostasis
GO:0045650 IMP negative regulation of macrophage differentiation
GO:0045722 IMP positive regulation of gluconeogenesis
GO:0046627 IMP negative regulation of insulin receptor signaling pathway
GO:0050728 IMP negative regulation of inflammatory response
GO:0050860 IMP negative regulation of T cell receptor signaling pathway
GO:0050922 IMP negative regulation of chemotaxis
GO:0060336 IMP negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 IMP negative regulation of type I interferon-mediated signaling pathway
GO:0070104 IMP negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:1902202 ISS regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 IMP negative regulation of interleukin-2-mediated signaling pathway
GO:1902212 IMP negative regulation of prolactin signaling pathway
GO:1902215 IMP negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 IMP negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 IMP negative regulation of positive thymic T cell selection
GO:2000587 IMP negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016481 ptpn2a protein tyrosine phosphatase, non-receptor type 2, a protein_coding Danio_rerio
ENSDARG00000035986 ptpn2b protein tyrosine phosphatase, non-receptor type 2, b protein_coding Danio_rerio
ENSG00000175354 PTPN2 protein tyrosine phosphatase, non-receptor type 2 protein_coding Homo_sapiens

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