C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: protein tyrosine phosphatase, non-receptor type 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000309660 PTPN2-002 ENSG00000175354 9606 - 18:12792153-12884235 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000309660
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000309660 0.807±0.00 0.405±0.00 1.041±0.37 1.370±0.61 0.433±0.00 0.483±0.12 1.140±0.00 0.477±0.00 1.215±0.15 1.097±0.05 0.452±0.05 1.217±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005Q0 CIL_0005Q0_0002 CGP 18:12661833-12929643
CIL_00068W CIL_00068W_0001 CGP 18:12785478-12987536

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004725 IMP:IEA protein tyrosine phosphatase activity
GO:0005178 IPI integrin binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005793 IDA endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 IDA plasma membrane
GO:0006470 IEA protein dephosphorylation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008286 ISS insulin receptor signaling pathway
GO:0010804 ISS negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 ISS negative regulation of lipid storage
GO:0016311 IEA dephosphorylation
GO:0016791 IEA phosphatase activity
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019901 IPI protein kinase binding
GO:0019905 IPI syntaxin binding
GO:0030183 ISS B cell differentiation
GO:0030217 ISS T cell differentiation
GO:0030218 ISS erythrocyte differentiation
GO:0030971 IPI receptor tyrosine kinase binding
GO:0035335 IMP peptidyl-tyrosine dephosphorylation
GO:0042059 IMP negative regulation of epidermal growth factor receptor signaling pathway
GO:0042512 IMP negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518 IDA negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524 ISS negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527 IMP negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042593 ISS glucose homeostasis
GO:0045650 ISS negative regulation of macrophage differentiation
GO:0045722 ISS positive regulation of gluconeogenesis
GO:0046627 ISS negative regulation of insulin receptor signaling pathway
GO:0050728 ISS negative regulation of inflammatory response
GO:0050860 ISS negative regulation of T cell receptor signaling pathway
GO:0050922 ISS negative regulation of chemotaxis
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060334 TAS regulation of interferon-gamma-mediated signaling pathway
GO:0060336 ISS negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 IMP negative regulation of type I interferon-mediated signaling pathway
GO:0070104 IMP negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:1902202 IMP regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 IMP negative regulation of interleukin-2-mediated signaling pathway
GO:1902212 ISS negative regulation of prolactin signaling pathway
GO:1902215 IMP negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 ISS negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 ISS negative regulation of positive thymic T cell selection
GO:2000587 ISS negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000122412 Ptpn2-002 protein_coding Mus_musculus 0 1899
ENSMUST00000025420 Ptpn2-001 protein_coding Mus_musculus 0 1351
ENSMUST00000120934 Ptpn2-003 protein_coding Mus_musculus 0 1112
ENSMUST00000128169 Ptpn2-004 processed_transcript Mus_musculus 0 773

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