C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SHANK-associated RH domain interactor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000179526 SHARPIN 9606 - 8:144098633-144108124 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359551 SHARPIN-002 144098637-144104237 nonsense_mediated_decay
  ENST00000398712 SHARPIN-001 144098637-144104190 protein_coding
  ENST00000525275 SHARPIN-010 144099301-144099989 retained_intron
  ENST00000530216 SHARPIN-009 144099250-144100842 retained_intron
  ENST00000531375 SHARPIN-007 144102817-144103756 retained_intron
  ENST00000532536 SHARPIN-011 144098633-144099322 protein_coding
  ENST00000533184 SHARPIN-008 144103117-144108124 processed_transcript
  ENST00000533948 SHARPIN-004 144099519-144104269 processed_transcript
  ENST00000534242 SHARPIN-005 144099291-144104250 processed_transcript
  ENST00000534435 SHARPIN-006 144102642-144104096 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartKidneyLiverLungOvaryPlacentaTestisENST00000398712
Transcript ID Adipose Adrenal Brain Breast Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000398712 35.112±0.00 19.758±0.00 4.936±0.00 26.866±0.00 18.785±0.00 13.577±11.00 13.350±0.00 29.564±0.00 34.856±2.59 30.380±2.95 46.723±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SS CIL_0007SS_0001 VISTA 8:143880613-144482307
CIL_00026W CIL_00026W_0001 CGP 8:144095027-144108124
CIL_0006Y3 CIL_0006Y3_0002 CGP 8:144098633-144108124

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005829 IDA cytosol
GO:0007005 IEA mitochondrion organization
GO:0007420 IEA brain development
GO:0008270 IEA zinc ion binding
GO:0008544 IEA epidermis development
GO:0010803 IDA regulation of tumor necrosis factor-mediated signaling pathway
GO:0014069 IEA postsynaptic density
GO:0030054 IEA cell junction
GO:0030262 IEA apoptotic nuclear changes
GO:0030425 IEA dendrite
GO:0031424 IEA keratinization
GO:0031593 IDA polyubiquitin binding
GO:0032403 IEA protein complex binding
GO:0042802 IEA identical protein binding
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050728 ISS negative regulation of inflammatory response
GO:0051260 IEA protein homooligomerization
GO:0071797 IDA LUBAC complex
GO:0097039 IDA protein linear polyubiquitination
GO:2000348 IDA regulation of CD40 signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059871 shrprbck1r sharpin and rbck1 related protein_coding Danio_rerio
ENSDARG00000076995 sharpin SHANK-associated RH domain interactor protein_coding Danio_rerio
ENSMUSG00000022552 Sharpin SHANK-associated RH domain interacting protein protein_coding Mus_musculus

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