C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SHANK-associated RH domain interacting protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022552 Sharpin 10090 - 15:76347040-76351111 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023211 Sharpin-001 76347040-76351111 protein_coding
  ENSMUST00000123112 Sharpin-002 76347040-76351110 retained_intron
  ENSMUST00000133993 Sharpin-005 76348612-76350712 retained_intron
  ENSMUST00000137106 Sharpin-007 76347897-76350682 retained_intron
  ENSMUST00000144816 Sharpin-003 76347041-76351075 retained_intron
  ENSMUST00000147001 Sharpin-009 76347118-76348195 retained_intron
  ENSMUST00000152151 Sharpin-011 76347849-76350691 retained_intron
  ENSMUST00000154477 Sharpin-004 76347041-76351047 retained_intron
  ENSMUST00000159429 Sharpin-008 76347054-76347684 protein_coding
  ENSMUST00000160560 Sharpin-010 76347629-76350750 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023211ENSMUST00000133993ENSMUST00000144816ENSMUST00000147001ENSMUST00000152151ENSMUST00000154477ENSMUST00000159429ENSMUST00000160560
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023211 15.138±0.72 22.782±2.95 22.497±2.53 14.852±7.46 16.834±6.50 24.054±1.77 9.533±2.03 19.042±1.22 14.491±1.79 18.385±1.02 14.198±0.97 18.417±8.36 7.770±2.99 15.950±7.97
ENSMUST00000133993 N/A N/A N/A N/A 2.224±0.00 N/A N/A N/A N/A N/A N/A 1.905±0.24 0.687±0.04 0.493±0.00
ENSMUST00000144816 7.307±1.09 7.699±1.30 9.935±2.16 11.230±4.34 9.445±2.74 11.198±1.23 3.269±0.42 6.459±0.58 5.894±1.62 12.029±1.13 N/A 8.153±2.60 3.739±1.39 3.594±2.26
ENSMUST00000147001 10.785±0.00 13.799±0.00 N/A N/A 19.421±0.80 N/A 6.936±0.82 N/A 9.581±1.66 N/A 8.308±0.00 9.159±0.33 N/A N/A
ENSMUST00000152151 N/A 18.623±4.31 N/A N/A N/A 14.118±0.00 N/A N/A N/A N/A N/A 16.282±0.00 N/A N/A
ENSMUST00000154477 4.013±0.34 6.228±1.45 N/A 3.492±0.00 6.701±0.51 N/A N/A 4.458±0.00 2.963±0.19 6.564±0.00 N/A 3.115±0.00 N/A N/A
ENSMUST00000159429 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 25.864±0.00 23.464±2.28 8.423±0.00
ENSMUST00000160560 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.942±1.57 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SS CIL_0007SS_0002 VISTA 15:76102685-76704351
CIL_00026W CIL_00026W_0002 CGP 15:76343523-76351111
CIL_0006Y3 CIL_0006Y3_0003 CGP 15:76347040-76354380

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005829 ISS cytosol
GO:0007005 IMP mitochondrion organization
GO:0007420 IEA brain development
GO:0008270 IEA zinc ion binding
GO:0008544 IMP epidermis development
GO:0010803 ISS regulation of tumor necrosis factor-mediated signaling pathway
GO:0014069 IEA postsynaptic density
GO:0030054 IEA cell junction
GO:0030262 IMP apoptotic nuclear changes
GO:0030425 IEA dendrite
GO:0031424 IMP keratinization
GO:0031593 ISS polyubiquitin binding
GO:0032403 IEA protein complex binding
GO:0042802 IEA identical protein binding
GO:0043123 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050728 IMP negative regulation of inflammatory response
GO:0051260 IEA protein homooligomerization
GO:0071797 ISS LUBAC complex
GO:0097039 ISS protein linear polyubiquitination
GO:2000348 ISS regulation of CD40 signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059871 shrprbck1r sharpin and rbck1 related protein_coding Danio_rerio
ENSDARG00000076995 sharpin SHANK-associated RH domain interactor protein_coding Danio_rerio
ENSG00000179526 SHARPIN SHANK-associated RH domain interactor protein_coding Homo_sapiens

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