C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: gremlin 2, DAN family BMP antagonist
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000180875 GREM2 9606 - 1:240489573-240612149 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000318160 GREM2-001 240489573-240612149 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000318160
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000318160 0.063±0.00 0.715±0.00 0.105±0.00 1.599±0.82 1.388±0.78 4.426±3.06 0.009±0.00 2.015±1.72 2.403±1.76 0.613±0.22 0.082±0.00 0.859±0.48 0.930±0.36 1.162±0.99

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006KG CIL_0006KG_0001 CGP 1:240014348-240612149
CIL_0000L0 CIL_0000L0_0002 CGP 1:240489573-241357230

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005125 IEA cytokine activity
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0008201 ISS heparin binding
GO:0010172 ISS embryonic body morphogenesis
GO:0019221 ISS cytokine-mediated signaling pathway
GO:0030509 TAS BMP signaling pathway
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0036122 IEA BMP binding
GO:0038098 IEA sequestering of BMP from receptor via BMP binding
GO:0042803 IEA protein homodimerization activity
GO:0048263 IEA determination of dorsal identity
GO:0060300 ISS regulation of cytokine activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005001 grem2 gremlin 2, cysteine knot superfamily protein_coding Danio_rerio
ENSDARG00000056057 GREM2 (2 of 2) gremlin 2, DAN family BMP antagonist protein_coding Danio_rerio
ENSMUSG00000050069 Grem2 gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) protein_coding Mus_musculus

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