C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000182054 IDH2 9606 - 15:90083045-90102504 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000330062 IDH2-001 90083045-90102504 protein_coding
  ENST00000540499 IDH2-004 90084177-90100695 protein_coding
  ENST00000559482 IDH2-002 90084014-90102477 protein_coding
  ENST00000560061 IDH2-003 90083996-90102468 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000330062ENST00000540499ENST00000559482ENST00000560061
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000330062 1.632±0.00 5.806±0.00 6.554±0.00 9.766±5.51 6.293±2.01 4.117±0.93 30.627±18.47 15.736±10.41 15.350±10.58 2.277±1.60 32.577±0.00 4.250±0.92 22.951±4.11 2.559±0.00
ENST00000540499 7.979±0.00 12.065±0.00 5.243±0.00 19.748±16.58 12.642±7.39 17.153±5.46 89.535±61.71 79.380±0.00 102.442±0.00 16.607±0.00 138.559±88.92 19.911±19.28 65.422±13.65 7.489±5.08
ENST00000559482 N/A N/A 3.775±0.00 N/A N/A N/A N/A N/A N/A 0.997±0.00 N/A 2.145±0.00 N/A N/A
ENST00000560061 9.200±0.00 23.753±0.00 4.135±0.00 8.770±0.00 15.004±12.61 18.980±8.49 75.157±51.95 61.226±0.00 65.112±59.09 16.325±0.00 138.448±42.82 18.052±15.02 50.041±2.33 7.890±5.22

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001T4 CIL_0001T4_0002 CGP 15:90001392-90102504
CIL_00079J CIL_00079J_0001 CGP 15:90083045-90229679

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0004450 ISS:IEA isocitrate dehydrogenase (NADP+) activity
GO:0005739 IDA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0005759 TAS mitochondrial matrix
GO:0005975 NAS carbohydrate metabolic process
GO:0006097 IEA glyoxylate cycle
GO:0006099 TAS tricarboxylic acid cycle
GO:0006102 ISS:IEA isocitrate metabolic process
GO:0006103 ISS 2-oxoglutarate metabolic process
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0051287 IEA NAD binding
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003795 IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial protein_coding Danio_rerio
ENSMUSG00000030541 Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial protein_coding Mus_musculus

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