C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: complement component 1, s subcomponent
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000182326 C1S 9606 + 12:6988259-7071032 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000328916 C1S-003 7060515-7071032 protein_coding
  ENST00000360817 C1S-004 7060676-7070943 protein_coding
  ENST00000402681 C1S-017 7060685-7070960 protein_coding
  ENST00000403949 C1S-007 7061384-7064380 protein_coding
  ENST00000406697 C1S-001 6988259-7071032 protein_coding
  ENST00000413211 C1S-006 7061212-7062985 protein_coding
  ENST00000423384 C1S-005 7061212-7062978 protein_coding
  ENST00000443875 C1S-002 7061839-7071030 nonsense_mediated_decay
  ENST00000461983 C1S-014 7066631-7070113 retained_intron
  ENST00000463798 C1S-011 7064178-7065412 retained_intron
  ENST00000470326 C1S-013 7066192-7067662 retained_intron
  ENST00000473545 C1S-012 7065240-7066313 retained_intron
  ENST00000488701 C1S-009 7060744-7062808 retained_intron
  ENST00000489541 C1S-008 7060717-7062228 retained_intron
  ENST00000495053 C1S-010 7063909-7065898 retained_intron
  ENST00000495061 C1S-016 7067091-7070240 processed_transcript
  ENST00000497061 C1S-015 7067395-7068530 retained_intron
  ENST00000541647 C1S-018 7060723-7065178 processed_transcript
  ENST00000542978 C1S-019 7062583-7066618 protein_coding
  ENST00000543187 C1S-020 7060725-7062808 processed_transcript
  ENST00000617865 C1S-201 7060676-7071029 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000328916ENST00000360817ENST00000402681ENST00000443875
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000328916 38.173±0.00 N/A N/A 3.097±2.18 26.364±11.08 39.376±29.46 2.302±0.00 117.400±0.00 17.898±0.00 8.690±0.00 N/A 243.496±220.88 N/A 65.002±0.00
ENST00000360817 70.895±0.00 N/A 3.452±0.00 1.572±0.00 43.012±0.00 31.325±15.13 18.987±14.43 145.094±125.47 101.086±71.53 36.490±21.17 8.668±2.74 43.953±28.03 24.367±0.00 20.230±0.00
ENST00000402681 66.531±0.00 118.970±0.00 4.523±0.00 6.878±0.00 33.685±11.63 64.223±56.50 12.852±10.34 42.214±24.49 159.509±0.00 45.140±35.99 11.107±0.00 168.907±0.00 19.838±5.03 64.627±32.01
ENST00000443875 48.694±0.00 120.917±0.00 N/A 5.629±0.00 45.556±0.00 118.714±0.00 24.021±0.00 22.719±0.00 197.142±0.00 70.349±0.00 10.554±0.00 200.230±0.00 14.974±2.64 125.127±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00001H CIL_00001H_0001 CGP 12:6988259-7092607

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003824 IEA catalytic activity
GO:0004252 IEA:IDA serine-type endopeptidase activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0006508 IEA proteolysis
GO:0006956 TAS complement activation
GO:0006958 TAS complement activation, classical pathway
GO:0042802 IPI identical protein binding
GO:0045087 TAS innate immune response
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011144 c1r complement component 1, r subcomponent protein_coding Danio_rerio
ENSDARG00000075719 C1S (2 of 3) complement component 1, s subcomponent protein_coding Danio_rerio
ENSDARG00000089722 C1S (3 of 3) complement component 1, s subcomponent protein_coding Danio_rerio
ENSMUSG00000038521 C1s1 complement component 1, s subcomponent 1 protein_coding Mus_musculus
ENSMUSG00000079343 C1s2 complement component 1, s subcomponent 2 protein_coding Mus_musculus

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