C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: parkin RBR E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185345 PARK2 9606 - 6:161347420-162727771 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338468 PARK2-003 161350099-162727668 protein_coding
  ENST00000366892 PARK2-002 161545112-162727764 protein_coding
  ENST00000366894 PARK2-001 161350099-162727668 protein_coding
  ENST00000366896 PARK2-006 161348639-162727771 protein_coding
  ENST00000366897 PARK2-005 161348639-162727771 protein_coding
  ENST00000366898 PARK2-004 161347420-162727771 protein_coding
  ENST00000479615 PARK2-007 161350099-162727668 nonsense_mediated_decay
  ENST00000610470 PARK2-201 161350099-161569420 protein_coding
  ENST00000612485 PARK2-202 161548754-161569420 protein_coding
  ENST00000612540 PARK2-203 162262526-162275386 protein_coding
  ENST00000615065 PARK2-204 162262461-162262768 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000338468ENST00000366892ENST00000366896ENST00000366897ENST00000366898ENST00000615065
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000338468 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.058±0.00 0.312±0.00 N/A
ENST00000366892 N/A N/A N/A N/A 1.030±0.00 N/A N/A 1.234±0.00 0.716±0.00 N/A N/A N/A 1.097±0.00
ENST00000366896 N/A 18.674±0.00 5.366±0.00 N/A N/A N/A N/A 1.720±0.00 N/A 7.981±0.00 N/A N/A N/A
ENST00000366897 N/A N/A 3.221±0.00 0.604±0.00 0.787±0.00 2.073±0.00 0.915±0.00 1.890±0.00 1.213±0.00 N/A 0.952±0.00 0.083±0.00 N/A
ENST00000366898 0.822±0.00 N/A 1.841±0.00 1.121±0.69 0.353±0.00 2.714±1.26 2.002±0.00 0.309±0.00 0.176±0.00 N/A 0.729±0.09 0.086±0.00 2.015±0.00
ENST00000615065 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.655±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007Y5 CIL_0007Y5_0001 VISTA 6:160860643-161462319

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IDA ubiquitin ligase complex
GO:0000209 IDA protein polyubiquitination
GO:0000266 ISS mitochondrial fission
GO:0000422 ISS mitochondrion degradation
GO:0001664 IPI G-protein coupled receptor binding
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0001964 IEA startle response
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IC nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IMP mitochondrion
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006513 IDA protein monoubiquitination
GO:0006979 ISS response to oxidative stress
GO:0007005 ISS mitochondrion organization
GO:0007417 TAS central nervous system development
GO:0007612 IEA learning
GO:0007626 IEA locomotory behavior
GO:0008219 IEA cell death
GO:0008270 TAS:IEA zinc ion binding
GO:0008344 ISS adult locomotory behavior
GO:0010506 IDA regulation of autophagy
GO:0010636 IMP positive regulation of mitochondrial fusion
GO:0010637 ISS negative regulation of mitochondrial fusion
GO:0010821 IDA regulation of mitochondrion organization
GO:0010906 TAS regulation of glucose metabolic process
GO:0014059 TAS regulation of dopamine secretion
GO:0016235 IDA aggresome
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0017124 TAS SH3 domain binding
GO:0019538 IEA protein metabolic process
GO:0019900 IPI kinase binding
GO:0019901 IPI protein kinase binding
GO:0030165 IPI PDZ domain binding
GO:0030544 IPI Hsp70 protein binding
GO:0031072 IPI heat shock protein binding
GO:0031624 IPI ubiquitin conjugating enzyme binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032232 IDA negative regulation of actin filament bundle assembly
GO:0032368 TAS regulation of lipid transport
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033132 IDA negative regulation of glucokinase activity
GO:0034620 TAS cellular response to unfolded protein
GO:0034976 IMP response to endoplasmic reticulum stress
GO:0035249 IEA synaptic transmission, glutamatergic
GO:0035519 TAS protein K29-linked ubiquitination
GO:0042415 IEA norepinephrine metabolic process
GO:0042417 TAS dopamine metabolic process
GO:0042787 TAS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IPI identical protein binding
GO:0043005 IEA neuron projection
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 IDA ubiquitin binding
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043234 IEA protein complex
GO:0043388 IDA positive regulation of DNA binding
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0044257 IMP cellular protein catabolic process
GO:0044314 TAS protein K27-linked ubiquitination
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046329 ISS negative regulation of JNK cascade
GO:0046676 IDA negative regulation of insulin secretion
GO:0046928 IEA regulation of neurotransmitter secretion
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050804 IEA regulation of synaptic transmission
GO:0051087 IPI chaperone binding
GO:0051583 IEA dopamine uptake involved in synaptic transmission
GO:0051865 IDA protein autoubiquitination
GO:0055069 ISS zinc ion homeostasis
GO:0060548 IDA negative regulation of cell death
GO:0061630 IDA ubiquitin protein ligase activity
GO:0070050 ISS neuron cellular homeostasis
GO:0070534 IDA protein K63-linked ubiquitination
GO:0070585 IEA protein localization to mitochondrion
GO:0070842 IMP aggresome assembly
GO:0070936 IDA protein K48-linked ubiquitination
GO:0071287 TAS cellular response to manganese ion
GO:0071797 IPI LUBAC complex
GO:0085020 TAS protein K6-linked ubiquitination
GO:0090141 ISS positive regulation of mitochondrial fission
GO:0090201 IDA negative regulation of release of cytochrome c from mitochondria
GO:0097237 IMP cellular response to toxic substance
GO:0097413 TAS Lewy body
GO:0097602 IDA cullin family protein binding
GO:1900407 ISS regulation of cellular response to oxidative stress
GO:1901215 IGI negative regulation of neuron death
GO:1901800 IGI positive regulation of proteasomal protein catabolic process
GO:1902236 IMP negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902530 IGI positive regulation of protein linear polyubiquitination
GO:1902803 NAS regulation of synaptic vesicle transport
GO:1903146 TAS regulation of mitochondrion degradation
GO:1903202 TAS negative regulation of oxidative stress-induced cell death
GO:1903265 IDA positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903351 TAS cellular response to dopamine
GO:1903377 IDA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903378 IEA positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903382 IEA negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990381 IPI ubiquitin-specific protease binding
GO:1990444 IPI F-box domain binding
GO:1990452 IPI Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000377 IMP regulation of reactive oxygen species metabolic process
GO:2000378 IGI negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021555 park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin protein_coding Danio_rerio
ENSMUSG00000023826 Park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin protein_coding Mus_musculus

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