C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Parkinson disease (autosomal recessive, juvenile) 2, parkin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000023826 Park2 10090 + 17:10840384-12063361 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066658 Park2-003 10840384-11557234 retained_intron
  ENSMUST00000097413 Park2-002 10840391-10945412 processed_transcript
  ENSMUST00000168593 Park2-201 11067125-11493173 protein_coding
  ENSMUST00000179624 Park2-202 11838602-11867561 protein_coding
  ENSMUST00000186167 Park2-004 10840384-11557234 retained_intron
  ENSMUST00000186406 Park2-007 11303647-11610945 protein_coding
  ENSMUST00000190849 Park2-005 11845210-11867561 processed_transcript
  ENSMUST00000190894 Park2-006 12029916-12063358 processed_transcript
  ENSMUST00000191124 Park2-001 10840384-12063361 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066658ENSMUST00000097413ENSMUST00000168593ENSMUST00000186167ENSMUST00000190894ENSMUST00000191124
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066658 N/A N/A N/A 1.624±0.00 N/A 0.365±0.07 N/A N/A 3.975±1.34 N/A N/A 1.084±0.00 0.298±0.16 N/A
ENSMUST00000097413 N/A N/A N/A N/A N/A N/A 0.274±0.07 N/A 0.021±0.01 N/A 0.192±0.00 N/A 0.031±0.00 N/A
ENSMUST00000168593 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.132±0.00 3.807±0.00
ENSMUST00000186167 0.888±0.15 1.296±0.68 1.865±0.00 1.269±0.00 1.098±0.56 0.752±0.31 1.291±0.34 1.578±0.45 0.610±0.51 1.071±0.17 1.314±0.26 0.764±0.21 0.125±0.03 2.518±0.32
ENSMUST00000190894 N/A N/A N/A N/A N/A 0.238±0.00 N/A N/A 0.031±0.00 N/A N/A 0.485±0.27 0.418±0.42 N/A
ENSMUST00000191124 2.077±0.90 1.485±0.72 1.263±0.01 1.251±0.79 0.970±0.30 0.310±0.13 0.807±0.43 1.780±0.49 0.365±0.33 1.189±0.06 1.318±0.38 1.436±0.63 0.158±0.10 6.147±2.43

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AN CIL_0009AN_0002 VISTA 17:10443926-11046179
CIL_000800 CIL_000800_0002 VISTA 17:10785724-11388280

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IEA ubiquitin ligase complex
GO:0000209 ISS protein polyubiquitination
GO:0000266 ISS mitochondrial fission
GO:0000422 ISS mitochondrion degradation
GO:0001664 IEA G-protein coupled receptor binding
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001963 IMP synaptic transmission, dopaminergic
GO:0001964 IMP startle response
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005829 IEA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006513 ISS protein monoubiquitination
GO:0006979 ISS response to oxidative stress
GO:0007005 ISS mitochondrion organization
GO:0007612 IMP learning
GO:0007626 IMP locomotory behavior
GO:0008270 IEA zinc ion binding
GO:0008344 IMP adult locomotory behavior
GO:0010506 ISS regulation of autophagy
GO:0010636 IEA positive regulation of mitochondrial fusion
GO:0010637 ISS negative regulation of mitochondrial fusion
GO:0010821 ISS regulation of mitochondrion organization
GO:0016235 IEA aggresome
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019538 IMP protein metabolic process
GO:0019900 IEA kinase binding
GO:0019901 IEA protein kinase binding
GO:0030054 IEA cell junction
GO:0030165 IEA PDZ domain binding
GO:0030544 IEA Hsp70 protein binding
GO:0031072 IEA heat shock protein binding
GO:0031624 IEA ubiquitin conjugating enzyme binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032232 IEA negative regulation of actin filament bundle assembly
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033132 IEA negative regulation of glucokinase activity
GO:0034976 IMP response to endoplasmic reticulum stress
GO:0035249 IMP synaptic transmission, glutamatergic
GO:0042415 IMP norepinephrine metabolic process
GO:0042417 IMP dopamine metabolic process
GO:0042787 ISS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IEA identical protein binding
GO:0043005 IDA neuron projection
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ISS ubiquitin binding
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043234 IDA protein complex
GO:0043388 IEA positive regulation of DNA binding
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0044257 IMP cellular protein catabolic process
GO:0045211 IEA postsynaptic membrane
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046329 ISS negative regulation of JNK cascade
GO:0046676 IEA negative regulation of insulin secretion
GO:0046928 IMP regulation of neurotransmitter secretion
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050804 IMP regulation of synaptic transmission
GO:0051087 IEA chaperone binding
GO:0051583 IMP dopamine uptake involved in synaptic transmission
GO:0051865 ISS protein autoubiquitination
GO:0055069 ISS zinc ion homeostasis
GO:0060548 IEA negative regulation of cell death
GO:0061630 IEA ubiquitin protein ligase activity
GO:0070050 ISS neuron cellular homeostasis
GO:0070534 IEA protein K63-linked ubiquitination
GO:0070585 IMP protein localization to mitochondrion
GO:0070842 IEA aggresome assembly
GO:0070936 ISS protein K48-linked ubiquitination
GO:0071797 IEA LUBAC complex
GO:0090141 ISS positive regulation of mitochondrial fission
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:0097237 IDA cellular response to toxic substance
GO:0097602 IEA cullin family protein binding
GO:1900407 ISS regulation of cellular response to oxidative stress
GO:1901215 IMP negative regulation of neuron death
GO:1901800 IEA positive regulation of proteasomal protein catabolic process
GO:1902236 IMP negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902530 IMP positive regulation of protein linear polyubiquitination
GO:1903265 IEA positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903377 IEA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903378 IMP positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903382 IMP negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990381 IEA ubiquitin-specific protease binding
GO:1990444 IEA F-box domain binding
GO:1990452 IEA Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000377 IEA regulation of reactive oxygen species metabolic process
GO:2000378 IEA negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021555 park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin protein_coding Danio_rerio
ENSG00000185345 PARK2 parkin RBR E3 ubiquitin protein ligase protein_coding Homo_sapiens

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