C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: parkin RBR E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000366896 PARK2-006 ENSG00000185345 9606 - 6:161348639-162727771 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainLiverMuscleENST00000366896
Transcript ID Bladder Brain Liver Muscle
ENST00000366896 18.674±0.00 5.366±0.00 1.720±0.00 7.981±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007Y5 CIL_0007Y5_0001 VISTA 6:160860643-161462319

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000151 IDA ubiquitin ligase complex
GO:0000209 IDA protein polyubiquitination
GO:0000266 ISS mitochondrial fission
GO:0000422 ISS mitochondrion degradation
GO:0001664 IPI G-protein coupled receptor binding
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IC nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IMP mitochondrion
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006513 IDA protein monoubiquitination
GO:0006979 ISS response to oxidative stress
GO:0007005 ISS mitochondrion organization
GO:0007417 TAS central nervous system development
GO:0008219 IEA cell death
GO:0008270 TAS:IEA zinc ion binding
GO:0008344 ISS adult locomotory behavior
GO:0010506 IDA regulation of autophagy
GO:0010636 IMP positive regulation of mitochondrial fusion
GO:0010637 ISS negative regulation of mitochondrial fusion
GO:0010821 IDA regulation of mitochondrion organization
GO:0010906 TAS regulation of glucose metabolic process
GO:0014059 TAS regulation of dopamine secretion
GO:0016235 IDA aggresome
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0017124 TAS SH3 domain binding
GO:0019900 IPI kinase binding
GO:0019901 IPI protein kinase binding
GO:0030165 IPI PDZ domain binding
GO:0030544 IPI Hsp70 protein binding
GO:0031072 IPI heat shock protein binding
GO:0031624 IPI ubiquitin conjugating enzyme binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032232 IDA negative regulation of actin filament bundle assembly
GO:0032368 TAS regulation of lipid transport
GO:0033132 IDA negative regulation of glucokinase activity
GO:0034620 TAS cellular response to unfolded protein
GO:0034976 IMP response to endoplasmic reticulum stress
GO:0035519 TAS protein K29-linked ubiquitination
GO:0042417 TAS dopamine metabolic process
GO:0042787 TAS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IPI identical protein binding
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 IDA ubiquitin binding
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043388 IDA positive regulation of DNA binding
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0044257 IMP cellular protein catabolic process
GO:0044314 TAS protein K27-linked ubiquitination
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046329 ISS negative regulation of JNK cascade
GO:0046676 IDA negative regulation of insulin secretion
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051087 IPI chaperone binding
GO:0051865 IDA protein autoubiquitination
GO:0055069 ISS zinc ion homeostasis
GO:0060548 IDA negative regulation of cell death
GO:0061630 IDA ubiquitin protein ligase activity
GO:0070050 ISS neuron cellular homeostasis
GO:0070534 IDA protein K63-linked ubiquitination
GO:0070842 IMP aggresome assembly
GO:0070936 IDA protein K48-linked ubiquitination
GO:0071287 TAS cellular response to manganese ion
GO:0071797 IPI LUBAC complex
GO:0085020 TAS protein K6-linked ubiquitination
GO:0090141 ISS positive regulation of mitochondrial fission
GO:0090201 IDA negative regulation of release of cytochrome c from mitochondria
GO:0097237 IMP cellular response to toxic substance
GO:0097413 TAS Lewy body
GO:0097602 IDA cullin family protein binding
GO:1900407 ISS regulation of cellular response to oxidative stress
GO:1901215 IGI negative regulation of neuron death
GO:1901800 IGI positive regulation of proteasomal protein catabolic process
GO:1902236 IMP negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902530 IGI positive regulation of protein linear polyubiquitination
GO:1902803 NAS regulation of synaptic vesicle transport
GO:1903146 TAS regulation of mitochondrion degradation
GO:1903202 TAS negative regulation of oxidative stress-induced cell death
GO:1903265 IDA positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903351 TAS cellular response to dopamine
GO:1903377 IDA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990381 IPI ubiquitin-specific protease binding
GO:1990444 IPI F-box domain binding
GO:1990452 IPI Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000377 IMP regulation of reactive oxygen species metabolic process
GO:2000378 IGI negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000191124 Park2-001 protein_coding Mus_musculus 0 821
ENSMUST00000186167 Park2-004 retained_intron Mus_musculus 0 276
ENSMUST00000066658 Park2-003 retained_intron Mus_musculus 0 276
ENSMUST00000179624 Park2-202 protein_coding Mus_musculus 0 243
ENSMUST00000168593 Park2-201 protein_coding Mus_musculus 0 224
ENSMUST00000190849 Park2-005 processed_transcript Mus_musculus 2e-33 148
ENSMUST00000186406 Park2-007 protein_coding Mus_musculus 6e-24 117

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