C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hepatocyte growth factor-regulated tyrosine kinase substrate
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185359 HGS 9606 + 17:81683326-81703138 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000329138 HGS-001 81683932-81702119 protein_coding
  ENST00000570355 HGS-016 81696601-81701127 retained_intron
  ENST00000570652 HGS-019 81701127-81703138 nonsense_mediated_decay
  ENST00000571237 HGS-013 81693870-81696987 protein_coding
  ENST00000571518 HGS-003 81683326-81688790 protein_coding
  ENST00000571647 HGS-002 81695956-81698356 retained_intron
  ENST00000571885 HGS-014 81695681-81696383 retained_intron
  ENST00000572392 HGS-008 81684033-81693750 protein_coding
  ENST00000573080 HGS-007 81691206-81693014 retained_intron
  ENST00000573320 HGS-018 81700792-81701974 protein_coding
  ENST00000573949 HGS-015 81696186-81702115 retained_intron
  ENST00000575058 HGS-012 81693675-81695930 retained_intron
  ENST00000575078 HGS-017 81700583-81701348 protein_coding
  ENST00000576087 HGS-010 81686267-81690830 retained_intron
  ENST00000576393 HGS-009 81683983-81690604 retained_intron
  ENST00000576498 HGS-004 81683984-81691830 retained_intron
  ENST00000577012 HGS-011 81684108-81688827 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000329138ENST00000571237ENST00000571518ENST00000572392ENST00000576498
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000329138 N/A 8.655±0.00 2.611±0.00 5.751±0.00 1.490±0.00 4.979±0.00 0.565±0.00 0.859±0.00 3.496±0.21 4.439±0.00 10.551±9.31 2.989±0.00 16.341±5.08 14.595±0.00
ENST00000571237 21.686±0.00 29.581±0.00 N/A N/A N/A 20.768±0.00 N/A N/A N/A N/A N/A N/A 41.075±0.00 56.655±14.81
ENST00000571518 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 44.626±0.00 53.356±0.00 77.662±0.00
ENST00000572392 14.392±0.00 19.472±0.00 5.766±0.00 5.492±0.00 N/A 6.517±0.00 7.674±0.00 N/A 4.244±0.00 N/A 27.537±0.00 N/A N/A 27.013±0.00
ENST00000576498 N/A N/A N/A N/A 4.506±0.00 N/A N/A 2.264±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002FQ CIL_0002FQ_0001 CGP 17:81666364-81683924
CIL_0003BA CIL_0003BA_0001 CGP 17:81681174-81703138
CIL_0004BU CIL_0004BU_0001 CGP 17:81683326-81707526

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005768 IDA endosome
GO:0005769 IDA early endosome
GO:0005829 TAS cytosol
GO:0006622 IMP protein targeting to lysosome
GO:0006886 IEA intracellular protein transport
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008285 TAS negative regulation of cell proliferation
GO:0008333 IEA endosome to lysosome transport
GO:0010324 IMP membrane invagination
GO:0010628 IMP positive regulation of gene expression
GO:0016020 IEA membrane
GO:0016197 NAS endosomal transport
GO:0019904 IPI protein domain specific binding
GO:0030141 IEA secretory granule
GO:0042059 TAS negative regulation of epidermal growth factor receptor signaling pathway
GO:0042176 TAS regulation of protein catabolic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0046426 IDA negative regulation of JAK-STAT cascade
GO:0046872 IEA metal ion binding
GO:0061024 TAS membrane organization
GO:0070062 IDA extracellular vesicular exosome
GO:0072657 IMP protein localization to membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020960 hgs hepatocyte growth factor-regulated tyrosine kinase substrate protein_coding Danio_rerio
ENSMUSG00000025793 Hgs HGF-regulated tyrosine kinase substrate protein_coding Mus_musculus

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